NDLI: Osseointegration in arthroplasty: can simvastatin promote bone response to implants?

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Osseointegration in arthroplasty: can simvastatin promote bone response to implants?

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Comment on Mohammed et al.: Intramedullary tibial nailing in distal third tibial fractures: distal locking screws and fracture non-union.

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Fixation of Mitchell's osteotomy with bioabsorbable pins for treatment of hallux valgus deformity.

Survival of massive allografts in segmental oncological bone defect reconstructions.

Comment on: Clinical examination versus ultrasonography in detecting developmental dysplasia of the hip.

Evaluation of blood loss during limb salvage surgery for pelvic tumours.

A systematic review of radiological outcomes of highly cross-linked polyethylene versus conventional polyethylene in total hip arthroplasty.

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Osseointegration in arthroplasty: can simvastatin promote bone response to implants?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Basarir, Kerem Erdemli, Bülent Can, Alp Erdemli, Esra Zeyrek, Tugba
Description	Country affiliation: Turkey Author Affiliation: Basarir K ( Department of Orthopaedic Surgery, Ankara University School of Medicine, Ankara, Turkey. basarirkerem@yahoo.com)
Abstract	Cementless fixation depends on bone ingrowth for long-term success. Simvastatin as a lipid lowering agent has been demonstrated to have osteoanabolic effects. This study was designed to measure the possible effect of simvastatin on implant osseointegration. Bilateral femoral implantation of titanium cylinders was performed in 20 rabbits. Blood lipid levels were measured pre- and postoperatively. Scanning electron microscopy (SEM) was used to measure the percentage of the surface of each implant in contact with bone and mechanical pull-out testing was performed. The blood lipid levels were significantly reduced in the simvastatin group. Histomorphometric examination revealed increased bone ingrowth and mechanical examination showed increased interface strength in the simvastatin group. Mechanical and histological data showed superior stability and osseous adaptation at the bone/implant interface for the simvastatin group. We conclude that simvastatin has potential as a means of enhancing bone ingrowth, which is a key factor in the longevity of cementless implants.
File Format	HTM / HTML
ISSN	03412695
e-ISSN	14325195
Journal	International Orthopaedics
Issue Number	3
Volume Number	33
Language	English
Publisher	Springer
Publisher Date	2009-06-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Orthopedics Arthroplasty, Replacement Hypolipidemic Agents Pharmacology Materials Testing Osseointegration Drug Effects Osteogenesis Simvastatin Animals Femur Ultrastructure Implants, Experimental Lipids Blood Microscopy, Electron, Scanning Models, Animal Physiology Rabbits Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Surgery

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