NDLI: Y chromosome STR haplotypes and the genetic structure of U.S. populations of African, European, and Hispanic ancestry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kayser, Manfred Brauer, Silke Schädlich, Hiltrud Prinz, Mechthild Batzer, Mark A. Zimmerman, Peter A. Boatin, B. A. Stoneking, Mark
Spatial Coverage	United States Europe Africa
Description	Country affiliation: Germany Author Affiliation: Kayser M ( Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany. kayser@eva.mpg.de)
Abstract	To investigate geographic structure within U.S. ethnic populations, we analyzed 1705 haplotypes on the basis of 9 short tandem repeat (STR) loci on the Y-chromosome from 9-11 groups each of African-Americans, European-Americans, and Hispanics. There were no significant differences in the distribution of Y-STR haplotypes among African-American groups, whereas European-American and Hispanic groups did exhibit significant geographic heterogeneity. However, the significant heterogeneity resulted from one sample; removal of that sample in each case eliminated the significant heterogeneity. Multidimensional scaling analysis of R(ST) values indicated that African-American groups formed a distinct cluster, whereas there was some intermingling of European-American and Hispanic groups. MtDNA data exist for many of these same groups; estimates of the European-American genetic contribution to the African-American gene pool were 27.5%-33.6% for the Y-STR haplotypes and 9%-15.4% for the mtDNA types. The lack of significant geographic heterogeneity among Y-STR and mtDNA haplotypes in U.S ethnic groups means that forensic DNA databases do not need to be constructed for separate geographic regions of the U.S. Moreover, absence of significant geographic heterogeneity for these two loci means that regional variation in disease susceptibility within ethnic groups is more likely to reflect cultural/environmental factors, rather than any underlying genetic heterogeneity.
File Format	HTM / HTML
ISSN	10889051
e-ISSN	15495469
Journal	Genome Research
Issue Number	4
Volume Number	13
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Genomics Chromosomes, Human, Y Genetics Genetics, Population Haplotypes Hispanic Americans Tandem Repeat Sequences Africa Dna, Mitochondrial Comparative Study Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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