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Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Holloway, Alisha K. Begun, David J. Siepel, Adam Pollard, Katherine S.
Description	Country affiliation: United States Author Affiliation: Holloway AK ( Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, California 95691, USA. akholloway@ucdavis.edu)
Abstract	Recent genomic sequencing of 10 additional Drosophila genomes provides a rich resource for comparative genomics analyses aimed at understanding the similarities and differences between species and between Drosophila and mammals. Using a phylogenetic approach, we identified 64 genomic elements that have been highly conserved over most of the Drosophila tree, but that have experienced a recent burst of evolution along the Drosophila melanogaster lineage. Compared to similarly defined elements in humans, these regions of rapid lineage-specific evolution in Drosophila differ dramatically in location, mechanism of evolution, and functional properties of associated genes. Notably, the majority reside in protein-coding regions and primarily result from rapid adaptive synonymous site evolution. In fact, adaptive evolution appears to be driving substitutions to unpreferred codons. Our analysis also highlights interesting noncoding genomic regions, such as regulatory regions in the gene gooseberry-neuro and a putative novel miRNA.
File Format	HTM / HTML
ISSN	10889051
e-ISSN	15495469
DOI	10.1101/gr.077131.108
Journal	Genome Research
Issue Number	10
Volume Number	18
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Genomics Drosophila Melanogaster Genetics Genome, Insect Animals Codon Conserved Sequence Evolution, Molecular Micrornas Metabolism Models, Genetic Molecular Sequence Data Phylogeny Regulatory Sequences, Nucleic Acid Comparative Study Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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