NDLI: Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

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Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ip, Joanna Y. Schmidt, Dominic Pan, Qun Ramani, Arun K. Fraser, Andrew G. Odom, Duncan T. Blencowe, Benjamin J.
Description	Country affiliation: Canada Author Affiliation: Ip JY ( Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.)
Abstract	The rate of RNA polymerase II (Pol II) elongation can influence splice site selection in nascent transcripts, yet the extent and physiological relevance of this kinetic coupling between transcription and alternative splicing (AS) is not well understood. We performed experiments to perturb Pol II elongation and then globally compared AS patterns with genome-wide Pol II occupancy. RNA binding and RNA processing functions were significantly enriched among the genes with Pol II elongation inhibition-dependent changes in AS. Under conditions that interfere with Pol II elongation, including cell stress, increased Pol II occupancy was detected in the intronic regions flanking the alternative exons in these genes, and these exons generally became more included. A disproportionately high fraction of these exons introduced premature termination codons that elicited nonsense-mediated mRNA decay (NMD), thereby further reducing transcript levels. Our results provide evidence that kinetic coupling between transcription, AS, and NMD affords a rapid mechanism by which cells can respond to changes in growth conditions, including cell stress, to coordinate the levels of RNA processing factors with mRNA levels.
File Format	HTM / HTML
ISSN	10889051
e-ISSN	15495469
DOI	10.1101/gr.111070.110
Journal	Genome Research
Issue Number	3
Volume Number	21
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Genomics Alternative Splicing Rna Polymerase Ii Metabolism Rna Stability Transcription, Genetic Codon, Nonsense Genetics Enzyme Inhibitors Pharmacology Exons Gene Expression Regulation Genome, Human Jurkat Cells Microarray Analysis Molecular Targeted Therapy Antagonists & Inhibitors Rna, Messenger Rna-binding Proteins Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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Differential Effects of Sumoylation on Transcription and Alternative Splicing by Transcription Elongation Regulator 1 (TCERG1)

Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production.

Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression.

Transcriptional elongation and alternative splicing.

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate.

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

Similar Documents

Differential Effects of Sumoylation on Transcription and Alternative Splicing by Transcription Elongation Regulator 1 (TCERG1)

Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production.

Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression.

Transcriptional elongation and alternative splicing.

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate.

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.