NDLI: Roles of reactive oxygen and nitrogen species in pain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salvemini, Daniela Little, Joshua W. Doyle, Timothy Neumann, William L.
Description	Country affiliation: United States Author Affiliation: Salvemini D ( Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. salvemd@slu.edu)
Abstract	Peroxynitrite (PN; ONOOâ») and its reactive oxygen precursor superoxide (SO; O2â¢â») are critically important in the development of pain of several etiologies including pain associated with chronic use of opiates such as morphine (also known as opiate-induced hyperalgesia and antinociceptive tolerance). This is now an emerging field in which considerable progress has been made in terms of understanding the relative contributions of SO, PN, and nitroxidative stress in pain signaling at the molecular and biochemical levels. Aggressive research in this area is poised to provide the pharmacological basis for development of novel nonnarcotic analgesics that are based upon the unique ability to selectively eliminate SO and/or PN. As we have a better understanding of the roles of SO and PN in pathophysiological settings, targeting PN may be a better therapeutic strategy than targeting SO. This is because, unlike PN, which has no currently known beneficial role, SO may play a significant role in learning and memory. Thus, the best approach may be to spare SO while directly targeting its downstream product, PN. Over the past 15 years, our team has spearheaded research concerning the roles of SO and PN in pain and these results are currently leading to the development of solid therapeutic strategies in this important area.
File Format	HTM / HTML
ISSN	08915849
e-ISSN	18734596
DOI	10.1016/j.freeradbiomed.2011.01.026
Journal	Free Radical Biology and Medicine
Issue Number	5
Volume Number	51
Language	English
Publisher	Elsevier
Publisher Date	2011-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Free radicals biology Analgesics Therapeutic Use Pain Drug Therapy Metabolism Reactive Nitrogen Species Reactive Oxygen Species Animals Drug Design Molecular Targeted Therapy Neurogenic Inflammation Physiopathology Peroxynitrous Acid Signal Transduction Drug Effects Superoxides Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.

Reactive oxygen species in cardiovascular disease.

Neuroprotective strategies involving ROS in Alzheimer disease.

Antioxidant Therapeutics: Pandora’s Box

Diabetic neutrophil mitochondrial dysfunction: an inflammatory situation?

The redox stress hypothesis of aging.

Reactive oxygen species, cellular redox systems, and apoptosis.

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.

Translational research involving oxidative stress and diseases of aging.

Roles of reactive oxygen and nitrogen species in pain.

Similar Documents

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.

Reactive oxygen species in cardiovascular disease.

Neuroprotective strategies involving ROS in Alzheimer disease.

Antioxidant Therapeutics: Pandora’s Box

Diabetic neutrophil mitochondrial dysfunction: an inflammatory situation?

The redox stress hypothesis of aging.

Reactive oxygen species, cellular redox systems, and apoptosis.

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.

Translational research involving oxidative stress and diseases of aging.

Roles of reactive oxygen and nitrogen species in pain.