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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pulkkinen, Kati H. Ylä-Herttuala, Seppo Levonen, Anna-Liisa |
| Description | Country affiliation: Finland Author Affiliation: Pulkkinen KH ( Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.) |
| Abstract | Heme oxygenase 1 (HO-1) is a stress-inducible enzyme that degrades redox-active heme-producing biliverdin, carbon monoxide, and Fe(2+). It protects cells under various stress conditions and mediates anti-inflammatory and vasodilatory effects in the endothelium. The expression of HMOX1, the HO-1 gene, is highly inducible and its transcriptional regulation is complex. HMOX1 is induced by various proinflammatory stimuli via NF-κB in human endothelial cells, but functional NF-κB-binding elements have not been identified from the human gene. However, the regulation of HMOX1 by the antioxidant-response element is firmly established, with the transcription factor BACH1 serving as a repressor and Nrf2 as an enhancer. miR-155 is one of the TNF -inducible endothelial microRNAs predicted to bind to the BACH1 mRNA. Oligonucleotides mimicking miR-155 efficiently inhibited BACH1 protein translation, resulting in a concentration-dependent increase in HMOX1 mRNA and protein expression in human umbilical vein endothelial cells. Moreover, endogenous miR-155 was upregulated by TNF via an NF-κB-dependent mechanism with a subsequent increase in HMOX1 expression. We propose that increased HMOX1 expression in endothelial cells by TNF results from miR-155-induced repression of BACH1 rather than direct induction of HMOX1 via NF-κB, and that miR-155 is cytoprotective during inflammation by elevating HO-1 expression in endothelial cells. |
| File Format | HTM / HTML |
| ISSN | 08915849 |
| Issue Number | 11 |
| Volume Number | 51 |
| e-ISSN | 18734596 |
| Journal | Free Radical Biology and Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Free radicals biology Basic-leucine Zipper Transcription Factors Metabolism Endothelial Cells Fanconi Anemia Complementation Group Proteins Heme Oxygenase-1 Micrornas Antagonists & Inhibitors Genetics Cells, Cultured Humans Rna, Messenger Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Biochemistry |
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