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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Serrano, Mariana P. Vignoni, Mariana Lorente, Carolina Vicendo, Patricia Oliveros, Esther Thomas, Andrés H. |
| Description | Country affiliation: Argentina Author Affiliation: Serrano MP ( Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), CCT La Plata-CONICET, Diagonal 113 y 64, 1900 La Plata, Argentina.); Vignoni M ( Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), CCT La Plata-CONICET, Diagonal 113 y 64, 1900 La Plata, Argentina.); Lorente C ( Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), CCT La Plata-CONICET, Diagonal 113 y 64, 1900 La Plata, Argentina.); Vicendo P ( Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique (IMRCP), UMR 5623-CNRS/UPS, Université Toulouse III (Paul Sabatier), 118, route de Narbonne, F-31062 Toulouse cédex 9, France.); Oliveros E ( Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique (IMRCP), UMR 5623-CNRS/UPS, Université Toulouse III (Paul Sabatier), 118, route de Narbonne, F-31062 Toulouse cédex 9, France.); Thomas AH ( Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), CCT La Plata-CONICET, Diagonal 113 y 64, 1900 La Plata, Argentina. Electronic address: athomas@inifta.unlp.edu.ar.) |
| Abstract | UV-A radiation (320-400nm), recognized as a class I carcinogen, induces damage to the DNA molecule and its components through different mechanisms. Pterin derivatives are involved in various biological functions, including enzymatic processes, and it has been demonstrated that oxidized pterins may act as photosensitizers. In particular, they accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder. We have investigated the ability of pterin (Ptr), the parent compound of oxidized pterins, to photosensitize the degradation of the pyrimidine nucleotide thymidine 5'-monophosphate (dTMP) in aqueous solutions under UV-A irradiation. Although thymine is less reactive than purine nucleobases, our results showed that Ptr is able to photoinduce the degradation of dTMP and that the process is initiated by an electron transfer from the nucleotide to the triplet excited state of Ptr. In the presence of molecular oxygen, the photochemical process leads to the oxidation of dTMP, whereas Ptr is not consumed. In the absence of oxygen, both compounds are consumed to yield a product in which the pterin moiety is covalently linked to the thymine. This compound retains some of the spectroscopic properties of Ptr, such as absorbance in the UV-A region and fluorescence properties. |
| File Format | HTM / HTML |
| ISSN | 08915849 |
| Journal | Free Radical Biology and Medicine |
| Volume Number | 96 |
| e-ISSN | 18734596 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Biochemistry |
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