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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yi, Dae Gwan Kim, Myung Ju Choi, Ji Eun Lee, Jihyun Jung, Joohee Huh, Won-Ki Chung, Woo-Hyun |
| Description | Author Affiliation: Yi DG ( Department of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Republic of Korea.); Kim MJ ( College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea); Choi JE ( College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea); Lee J ( College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea); Jung J ( College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea); Huh WK ( Department of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Republic of Korea.); Chung WH ( College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea) |
| Abstract | Reactive oxygen species (ROS)-mediated DNA adducts as well as DNA strand breaks are highly mutagenic leading to genomic instability and tumorigenesis. DNA damage repair pathways and oxidative stress response signaling have been proposed to be highly associated, but the underlying interaction remains unknown. In this study, we employed mutant strains lacking Rad51, the homolog of E. coli RecA recombinase, and Yap1 or Skn7, two major transcription factors responsive to ROS, to examine genetic interactions between double-strand break (DSB) repair proteins and cellular redox regulators in budding yeast Saccharomyces cerevisiae. Abnormal expression of YAP1 or SKN7 aggravated the mutation rate of rad51 mutants and their sensitivity to DSB- or ROS-generating reagents. Rad51 deficiency exacerbated genome instability in the presence of increased levels of ROS, and the accumulation of DSB lesions resulted in elevated intracellular ROS levels. Our findings suggest that evident crosstalk between DSB repair pathways and ROS signaling proteins contributes to cell survival and maintenance of genome integrity in response to genotoxic stress. |
| File Format | HTM / HTML |
| ISSN | 08915849 |
| Journal | Free Radical Biology and Medicine |
| Volume Number | 101 |
| e-ISSN | 18734596 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Biochemistry |
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