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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Xian-De Liu, Wen-Guang Guan, Yun-Yan Shi, Yu Wang, Qi Zhao, Mi Wu, Shan-Zeng He, Mao-Xian |
| Description | Author Affiliation: Huang XD ( Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.) |
| Abstract | NF-κB transcription factors play central roles in many important physiological and pathological processes including innate immune responses. Here we report the cloning of an NF-κB transcription factor, PfRelish from pearl oyster Pinctada fucata, one of the most important bivalve mollusks for seawater pearl production. PfRelish full-length cDNA is 3916 bp with an open reading frame of 3558 bp encoding a putative protein of 1186 amino acids. The deduced PfRelish contains a N-terminal RHD, a nucleus localization signal, an IκB-like domain with six ankyrin repeats and a death domain at the C-terminus, which is similar to class I NF-κB transcription factors. Comparison and phylogenetic analysis revealed that class I NF-κBs in mollusks including PfRelish might have most distant relationship to the arthropod Relish. Further expression analysis showed that PfRelish was apparently upregulated after Vibrio alginolyticus injection, which suggested that PfRelish was involved in the immune response to V. alginolyticus. |
| File Format | HTM / HTML |
| ISSN | 10504648 |
| Issue Number | 3 |
| Volume Number | 33 |
| e-ISSN | 10959947 |
| Journal | Fish & Shellfish Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Marine Biology Discipline Immunology Nf-kappa B Genetics Pinctada Immunology Amino Acid Sequence Animals Base Sequence Dna, Complementary Gene Expression Profiling Gene Expression Regulation Immunity, Innate Molecular Sequence Data Chemistry Metabolism Organ Specificity Phylogeny Microbiology Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Vibrio Alginolyticus Physiology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Medicine Aquatic Science Immunology |
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