NDLI: The flavoprotein FerB of Paracoccus denitrificans binds to membranes, reduces ubiquinone and superoxide, and acts as an in vivo antioxidant.

Please wait, while we are loading the content...

Positive lymph-node breast cancer patients activation of NF-κB in tumor-associated leukocytes stimulates cytokine secretion that promotes metastasis via C-C chemokine receptor CCR7.

The flavoprotein FerB of Paracoccus denitrificans binds to membranes, reduces ubiquinone and superoxide, and acts as an in vivo antioxidant.

PINK1 and Parkin mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.

Modeling the effects of commonly used drugs on human metabolism.

The intramolecular disulfide-stapled structure of laterosporulin, a class IId bacteriocin, conceals a human defensin-like structural module.

In vivo identification of the steps that control energy metabolism and survival of Entamoeba histolytica.

Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.

NMR structure of bitistatin a missing piece in the evolutionary pathway of snake venom disintegrins.

ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway.

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7.

Identification of two p23 co-chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities.

Sp1 and the 'hallmarks of cancer'.

Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase from Aspergillus fumigatus.

Year: 2015 Volume: 282 Issue: 1

Year: 2015 Volume: 282 Issue: Supplementary 1

Year: 2014 Volume: 281

Year: 2013 Volume: 280

Year: 2012 Volume: 279

Year: 2011 Volume: 278

Year: 2010 Volume: 277

Year: 2009 Volume: 276

Year: 2008 Volume: 275

Year: 2007 Volume: 274

Year: 2006 Volume: 273

Year: 2005 Volume: 272

The flavoprotein FerB of Paracoccus denitrificans binds to membranes, reduces ubiquinone and superoxide, and acts as an in vivo antioxidant.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sedlácek, Vojtech Ptácková, Nikola Rejmontová, Petra Kucera, Igor
Description	Country affiliation: Czech Republic Author Affiliation: Sedlácek V ( Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.)
Abstract	UNLABELLED: FerB is a flavin mononucleotide (FMN)-containing NAD(P)H: acceptor oxidoreductase of unknown function that is found in the cytoplasm of the bacterium Paracoccus denitrificans. Based on measurements of fluorescence anisotropy, we report here that recombinant FerB readily binds to artificial membrane vesicles. If ubiquinone is incorporated into the membrane, FerB catalyzes its conversion to ubihydroquinone, which may be followed fluorimetrically (with ferricyanide and pyranine entrapped inside the liposomes) or by HPLC. FerB also reduces exogenously added superoxide or superoxide that has been enzymatically generated by the xanthine/xanthine oxidase system or P. denitrificans membrane vesicles. In whole cells, deficiency of FerB increases sensitivity to methyl viologen, as indicated by a lower growth rate and increased production of reactive aldehydes (by-products of lipid oxidation). Taken together, these data support a role for FerB in protection of cells against lipid peroxidation-mediated oxidative stress, and suggest that FerB is a prokaryotic counterpart of mammalian NAD(P)H: quinone oxidoreductase 1.
File Format	HTM / HTML
ISSN	1742464X
Issue Number	2
Volume Number	282
e-ISSN	17424658
Journal	FEBS Journal
Language	English
Publisher	Wiley (on behalf of the Federation of European Biochemical Societies)
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Antioxidants Metabolism Flavoproteins Membrane Proteins Oxidative Stress Animals Chemistry Kinetics Oxidation-reduction Paracoccus Denitrificans Enzymology Superoxides Ubiquinone Xanthine Xanthine Oxidase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide

Re-evaluation of superoxide scavenging capacity of xanthohumol.

Single-electron reduction of the oxidized state is coupled to proton uptake via the K pathway in Paracoccus denitrificans cytochrome c oxidase.

Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe

Functional role of mitochondrial respiratory supercomplexes☆

The Cytochrome c Oxidase from Paracoccus denitrificans Does Not Change the Metal Center Ligation upon Reduction

Paracoccus denitrificans proton-translocating ATPase: Kinetics of oxidative phosphorylation

The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans.

Oxidative Half-reaction of Arabidopsis thaliana Sulfite Oxidase: GENERATION OF SUPEROXIDE BY A PEROXISOMAL ENZYME

The flavoprotein FerB of Paracoccus denitrificans binds to membranes, reduces ubiquinone and superoxide, and acts as an in vivo antioxidant.

Similar Documents

Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide

Re-evaluation of superoxide scavenging capacity of xanthohumol.

Single-electron reduction of the oxidized state is coupled to proton uptake via the K pathway in Paracoccus denitrificans cytochrome c oxidase.

Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe

Functional role of mitochondrial respiratory supercomplexes☆

The Cytochrome c Oxidase from Paracoccus denitrificans Does Not Change the Metal Center Ligation upon Reduction

Paracoccus denitrificans proton-translocating ATPase: Kinetics of oxidative phosphorylation

The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans.

Oxidative Half-reaction of Arabidopsis thaliana Sulfite Oxidase: GENERATION OF SUPEROXIDE BY A PEROXISOMAL ENZYME

The flavoprotein FerB of Paracoccus denitrificans binds to membranes, reduces ubiquinone and superoxide, and acts as an in vivo antioxidant.