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Efficient transposition of the youngest miniature inverted repeat transposable element family of yellow fever mosquito in yeast.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fattash, Isam Lee, Chia-Ni Mo, Kaiguo Yang, Guojun
Description	Country affiliation: Canada Author Affiliation: Fattash I ( Department of Biology, University of Toronto Mississauga, ON, Canada.); Lee CN ( Department of Biology, University of Toronto Mississauga, ON, Canada.); Mo K ( Department of Biology, University of Toronto Mississauga, ON, Canada.); Yang G ( Department of Biology, University of Toronto Mississauga, ON, Canada.)
Abstract	Miniature inverted repeat transposable elements (MITEs) are often the most numerous DNA transposons in plant and animal genomes. The dramatic amplification of MITE families during evolution is puzzling, because the transposase sources for the vast majority of MITE families are unknown. The yellow fever mosquito genome contains > 220-Mb MITE sequences; however, transposition activity has not been demonstrated for any of the MITE families. The Gnome elements are the youngest MITE family in this genome, with at least 116 identical copies. To test whether the putative autonomous element Ozma is capable of mobilizing Gnome and its two sibling MITEs, analyses were performed in a yeast transposition assay system. Whereas the wild-type transposase resulted in very low transposition activity, mutations in the region containing a putative nuclear export signal motif resulted in a dramatic (at least 4160-fold) increase in transposition frequency. We have also demonstrated that each residue of the novel DD37E motif is required for the activity of the Ozma transposase. Footprint sequences left at the donor sites suggest that the transposase may cleave between the second and the third nucleotides from the 5' ends of the elements. The excised elements reinsert specifically at dinucleotide 'TA', ~ 55% of them in yeast genes. The elements described in this article could potentially be useful as genetic tools for genetic manipulation of mosquitoes.
File Format	HTM / HTML
ISSN	1742464X
Issue Number	10
Volume Number	282
e-ISSN	17424658
Journal	FEBS Journal
Language	English
Publisher	Wiley (on behalf of the Federation of European Biochemical Societies)
Publisher Date	2015-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Culicidae Genetics Dna Transposable Elements Inverted Repeat Sequences Transposases Metabolism Animals Saccharomyces Cerevisiae Editorial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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