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Molecular imaging of vessels in mouse models of disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zagorchev, Lyubomir Mulligan-Kehoe, Mary J.
Description	Country affiliation: United States Author Affiliation: Zagorchev L ( Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA.)
Abstract	Vascular imaging of angiogenesis in mouse models of disease requires multi modal imaging hardware capable of targeting both structure and function at different physical scales. The three dimensional (3D) structure and function vascular information allows for accurate differentiation between biological processes. For example, image analysis of vessel development in angiogenesis vs. arteriogenesis enables more accurate detection of biological variation between subjects and more robust and reliable diagnosis of disease. In the recent years a number of micro imaging modalities have emerged in the field as preferred means for this purpose. They provide 3D volumetric data suitable for analysis, quantification, validation, and visualization of results in animal models. This review highlights the capabilities of microCT, ultrasound and microPET for multimodal imaging of angiogenesis and molecular vascular targets in a mouse model of tumor angiogenesis. The basic principles of the imaging modalities are described and experimental results are presented.
File Format	HTM / HTML
ISSN	0720048X
e-ISSN	18727727
DOI	10.1016/j.ejrad.2009.01.053
Journal	European Journal of Radiology
Issue Number	2
Volume Number	70
Language	English
Publisher	Elsevier
Publisher Date	2009-05-01
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Discipline Radiology Angiography Diagnostic Imaging Disease Models, Animal Molecular Probe Techniques Neoplasms Diagnosis Neovascularization, Pathologic Animals Mice Blood Supply Complications Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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