NDLI: Differentiation of adrenal adenomas from nonadenomas using CT histogram analysis method: a prospective study.

Please wait, while we are loading the content...

Diagnostic value of sonography, ultrasound-guided fine-needle aspiration cytology, and diffusion-weighted MRI in the characterization of cold thyroid nodules.

Assessment of triple-phase CT findings for the differentiation of fat-deficient hepatic angiomyolipoma from hepatocellular carcinoma in non-cirrhotic liver.

First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis.

Osteoradionecrosis of the upper cervical spine: MR imaging following radiotherapy for nasopharyngeal carcinoma.

Percutaneous needle aspiration biopsy (PCNAB) of lung lesions: 5 years results with focusing on repeat PCNAB.

Regenerative nodules in patients with chronic Budd-Chiari syndrome: a longitudinal study using multiphase contrast-enhanced multidetector CT.

In vivo quantification of intracerebral GABA by single-voxel (1)H-MRS-How reproducible are the results?

Early and late-onset acute GvHD following hematopoietic cell transplantation: CT features of gastrointestinal involvement with clinical and pathological correlation.

Fever of unknown origin: a value of (18)F-FDG-PET/CT with integrated full diagnostic isotropic CT imaging.

Synchrotron-based intra-venous K-edge digital subtraction angiography in a pig model: a feasibility study.

Thin-section CT of the mediastinum in preoperative N-staging of non-small cell lung cancer: comparison with FDG PET.

Glioblastoma treated with postoperative radio-chemotherapy: prognostic value of apparent diffusion coefficient at MR imaging.

Effect of different saline chaser volumes and flow rates on intravascular contrast enhancement in CT using a circulation phantom.

PET and PET/CT in endocrine tumours.

Dual-modality PET/CT instrumentation-today and tomorrow.

PET/CT: More than the sum of two established imaging modalities?

PET/CT imaging: The incremental value of assessing the glucose metabolic phenotype and the structure of cancers in a single examination.

Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis.

Basics and principles of radiopharmaceuticals for PET/CT.

PET/CT challenge for the non-invasive diagnosis of coronary artery disease.

Year: 2010 Volume: 73 Issue: 2

Year: 2010 Volume: 73 Issue: 1

Year: 2009 Volume: 72

Year: 2009 Volume: 71

Year: 2009 Volume: 70

Year: 2009 Volume: 69

Year: 2008 Volume: 68

Year: 2008 Volume: 67

Year: 2008 Volume: 66

Year: 2008 Volume: 65

Year: 2007 Volume: 64

Year: 2006 Volume: 59

Differentiation of adrenal adenomas from nonadenomas using CT histogram analysis method: a prospective study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Halefoglu, Ahmet Mesrur Bas, Nagihan Yasar, Ahmet Basak, Muzaffer
Description	Country affiliation: Turkey Author Affiliation: Halefoglu AM ( Department of Radiology, Sisli Etfal Training and Research Hospital, Sisli, Istanbul, Turkey. halefoglu@hotmail.com)
Abstract	OBJECTIVE: The objective of our study was to prospectively evaluate the effectiveness of computed tomography (CT) histogram analysis method in the differentiation of benign and malignant adrenal masses. MATERIALS AND METHODS: Between March 2007 and June 2008, 94 patients (46 males, 48 females, age range: 30-79 years, mean age: 57.7 years) with 113 adrenal masses (mean diameter: 3.03 cm, range: 1.07-8.02 cm) were prospectively evaluated. These included 66 adenomas, 45 metastases and 2 pheochromocytomas. Histogram analysis method was performed using a circular region of interest (ROI) and mean attenuation, total number of pixels, number of negative pixels and subsequent percentage of negative pixels were detected on both unenhanced and delayed contrast-enhanced CT images for each adrenal mass. A mean attenuation threshold of 10Hounsfield unit (HU) for unenhanced CT and 5% and 10% negative pixel thresholds for both unenhanced and delayed contrast-enhanced CT were calculated by a consensus of at least two reviewers and the correlation between mean attenuation and percentage of negative pixels was determined. Final diagnoses were based on imaging follow-up of minimum 6 months, biopsy, surgery and adrenal washout study. RESULTS: 51 of 66 adenomas (77.3%) showed attenuation values of < or =10HU and 15 (22.7%) adenomas showed more than 10HU on unenhanced CT. All of these adenomas contained negative pixels on unenhanced CT. Eight of 66 (12.1%) adenomas showed a mean attenuation value of < or =10HU on delayed contrast-enhanced scans and 45 adenomas (68.2%) persisted on containing negative pixels. All metastases had an attenuation value of greater than 10HU on unenhanced CT images. 21 of 45 (46.6%) metastases contained negative pixels on unenhanced images but only seven metastases (15.5%) had negative pixels on delayed contrast-enhanced images. Two pheochromocytomas had negative pixels on both unenhanced and delayed contrast-enhanced CT images. Increase in the percentage of negative pixels yielded high correlation with mean attenuation decreases, both on unenhanced and delayed contrast-enhanced CT. Our sensitivity was 90.9% for the 10% negative pixel percentage threshold compared to 77.2% sensitivity for < or =10HU mean attenuation threshold for unenhanced CT. Both methods gave a 100% specificity for the diagnosis of adenoma. We also obtained a 37.9% sensitivity for 5% negative pixel threshold and a slightly lower sensitivity of 28.8% for 10% negative pixel threshold compared to the 12.1% sensitivity of < or =10HU mean attenuation threshold while maintaining 100% specificity for contrast-enhanced CT. CONCLUSION: The CT histogram analysis is a simple and easily applicable method which provides higher sensitivity than the commonly used 10HU threshold mean attenuation method of unenhanced CT and can replace it for the diagnosis of an adenoma. But with contrast-enhanced CT, although 100% specificity is being maintained, the sensitivities obtained are very poor for each method and is therefore likely to limit CT histogram analysis to be used as a clinically useful adjunct in the diagnosis of adenoma.
File Format	HTM / HTML
ISSN	0720048X
Issue Number	3
Volume Number	73
e-ISSN	18727727
Journal	European Journal of Radiology
Language	English
Publisher	Elsevier
Publisher Date	2010-03-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Radiology Adrenal Gland Neoplasms Adrenocortical Adenoma Pheochromocytoma Tomography, Spiral Computed Methods Adult Aged Contrast Media Diagnosis, Differential Female Humans Iohexol Analogs & Derivatives Male Middle Aged Prospective Studies Sensitivity And Specificity Journal Article
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Incidental adrenal lesions: Accuracy of quadriphasic contrast enhanced computed tomography in distinguishing adenomas from nonadenomas.

Application of CT perfusion imaging to the histological differentiation of adrenal gland tumors.

Differentiation between benign and malignant adrenal mass using contrast-enhanced ultrasound.

Evaluate the efficacy of minimum attenuation value in differentiation of adrenal adenomas from nonadenomas on unenhanced CT.

Diagnostic Value of Unenhanced CT Attenuation and CT Histogram Analysis in Differential Diagnosis of Adrenal Tumors

Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics.

First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis.

Differentiation of adrenal tumors in patients with hepatocellular carcinoma: adrenal adenoma versus metastasis.

The clinical and CT imaging features of metanephric adenoma.

Differentiation of adrenal adenomas from nonadenomas using CT histogram analysis method: a prospective study.

Similar Documents

Incidental adrenal lesions: Accuracy of quadriphasic contrast enhanced computed tomography in distinguishing adenomas from nonadenomas.

Application of CT perfusion imaging to the histological differentiation of adrenal gland tumors.

Differentiation between benign and malignant adrenal mass using contrast-enhanced ultrasound.

Evaluate the efficacy of minimum attenuation value in differentiation of adrenal adenomas from nonadenomas on unenhanced CT.

Diagnostic Value of Unenhanced CT Attenuation and CT Histogram Analysis in Differential Diagnosis of Adrenal Tumors

Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics.

First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis.

Differentiation of adrenal tumors in patients with hepatocellular carcinoma: adrenal adenoma versus metastasis.

The clinical and CT imaging features of metanephric adenoma.

Differentiation of adrenal adenomas from nonadenomas using CT histogram analysis method: a prospective study.