NDLI: Correlations between ADC values and molecular markers of Ki-67 and HIF-1 in hepatocellular carcinoma.

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Correlations between ADC values and molecular markers of Ki-67 and HIF-1 in hepatocellular carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Zhaoqin Xu, Xiuqin Meng, Xiangjiao Hou, Zhongyu Liu, Fang Hua, Qianqian Liu, Qingwei Xiu, Jianjun
Description	Country affiliation: China Author Affiliation: Huang Z ( Radiology Department, Shandong Provincial Hospital Affiliated to Shandong University, Jingwu Road 324#, 250021, Jinan City, Shandong Province, China.); Xu X ( Department of Oncology, The People's Hospital of Haiyang County, China.); Meng X ( Department of Radiation Oncology of Shandong Cancer Hospital and Institute, Jiyan Road 440#, Jinan City, Shandong Province, China.); Hou Z ( Radiology Department, Shandong Provincial Hospital Affiliated to Shandong University, Jingwu Road 324#, 250021, Jinan City, Shandong Province, China.); Liu F ( Radiology Department, Shandong Provincial Hospital Affiliated to Shandong University, Jingwu Road 324#, 250021, Jinan City, Shandong Province, China.); Hua Q ( Radiology Department, Shandong Provincial Hospital Affiliated to Shandong University, Jingwu Road 324#, 250021, Jinan City, Shandong Province, China.); Liu Q ( Radiology Department, Shandong Provincial Hospital Affiliated to Shandong University, Jingwu Road 324#, 250021, Jinan City, Shandong Province, China.); Xiu J ( Radiology Department, Shandong Provincial Hospital Affiliated to Shandong University, Jingwu Road 324#, 250021, Jinan City, Shandong Province, China. Electronic address: xjjxrx@sina.com.)
Abstract	OBJECTIVE: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. Cell proliferativity and hypoxia have important impact on the response to radiotherapy or chemotherapy. The purpose of this study was to investigate the association of apparent diffusion coefficient (ADC) values and the molecular markers Ki-67 and hypoxia inducible factor- (HIF- ) in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Forty-seven patients diagnosed with HCC were included in this study. All patients performed diffusion-weighted magnetic resonance imaging (DW-MRI) before any anticancer treatment. The ADC maps were automatically calculated on a Syngo workstation. The Ki-67 and HIF-1 expression were assessed by immunohistochemistry. The Pearson correlation test was used to assess the correlation between ADC values and Ki-67 and HIF-1 expression. RESULTS: Ki-67 staining was clearly identified based on the brown nuclear staining in tumor cells. High Ki-67 expression was correlated with low differentiation (p=0.028). A significant correlation was observed between HIF-1 expression and maximum diameter (p=0.014). The mean ADC value was (0.983±0.21)×10(-3) mm(2)/s. The level of Ki-67 expression was correlated inversely with the ADC values (r=-0.371, p=0.01). There was a significant positive correlation between the ADC values and HIF-1 expression (r=0.389, p=0.007). CONCLUSION: The ADC values were observed to correlate significantly with the molecular markers Ki-67 and HIF-1 . Our results suggest that the ADC values on DW-MRI may be used as a measure of cell proliferativity and hypoxia in hepatocellular carcinoma.
File Format	HTM / HTML
ISSN	0720048X
Issue Number	12
Volume Number	84
e-ISSN	18727727
Journal	European Journal of Radiology
Language	English
Publisher	Elsevier
Publisher Date	2015-12-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Radiology Carcinoma, Hepatocellular Metabolism Hypoxia-inducible Factor 1, Alpha Subunit Ki-67 Antigen Liver Neoplasms Adult Aged Tumor Markers, Biological Genetics Cell Proliferation Diffusion Magnetic Resonance Imaging Methods Female Humans Anoxia Male Middle Aged Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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