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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shetty, Shrimati Patil, Rucha Ghosh, Kanjaksha |
| Description | Country affiliation: India Author Affiliation: Shetty S ( National Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai, India. shrimatishetty@gmail.com) |
| Abstract | The multiple functions attributed to microparticles (MPs) include blood coagulation, inflammation, tumorigenesis, angiogenesis, immunomodulatory functions and intercellular cross talk. These have drawn considerable interest during the last few years. The prothrombotic nature of MPs has linked them with almost all groups of thrombotic disorders including recurrent miscarriage (RM) and other abnormal pregnancy outcomes. Two authors (SS and RP) conducted a search independently on the computerized databases MEDLINE and EMBASE using relevant key words. Contradictory reports were observed on the association of MPs with RM. While most of the reports showed increased prevalence of MPs, both platelet and endothelial cell derived, in RM, some did not show any association. Almost all the reports showed a strong association of MPs with preeclampsia (PE), while the association with other adverse pregnancy conditions was not very conclusive. It may be concluded that MPs by themselves may result in adverse conditions or that they may be additive factors to an already existing prothrombotic state due to acquired or genetic thrombophilia or some unknown thrombophilic condition, besides the pre-existing hypercoagulable status of pregnancy. |
| File Format | HTM / HTML |
| ISSN | 03012115 |
| Issue Number | 2 |
| Volume Number | 169 |
| e-ISSN | 18727654 |
| Journal | European Journal of Obstetrics & Gynecology and Reproductive Biology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Obstetrics Discipline Gynecology Abortion, Habitual Metabolism Cell-derived Microparticles Pre-eclampsia Physiopathology Female Humans Pregnancy Case Reports Journal Article Review |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Reproductive Medicine Obstetrics and Gynecology |
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