NDLI: Meningeal cells induce dopaminergic neurons from embryonic stem cells.

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Year: 2008 Volume: 27 Issue: 1

Year: 2007 Volume: 26

Meningeal cells induce dopaminergic neurons from embryonic stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hayashi, Hideki Morizane, Asuka Koyanagi, Masaomi Ono, Yuichi Sasai, Yoshiki Hashimoto, Nobuo Takahashi, Jun
Description	Country affiliation: Japan Author Affiliation: Hayashi H ( Department of Biological Repair, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.)
Abstract	Neural induction of midbrain dopaminergic (DA) neurons from embryonic stem (ES) cells can be achieved by culturing them on a bone marrow-derived stromal cell line, PA6, which possesses stromal cell-derived inducing activity (SDIA). The mechanism of SDIA is unknown, but clinical application of ES cell transplantation requires the use of defined factors for DA neuron induction. Here, we demonstrate that meningeal cells harvested from the developing dura can induce DA neuron differentiation from mouse and human ES cells, as assessed by midbrain DA marker expression and secretion of DA in response to potassium stimuli. Intriguingly, the inductive strength of meningeal cells depends on their developmental stage, with those harvested from embryonic day 18 embryos showing the highest activity. Among six soluble factors known to be involved in DA neuron differentiation, only Wnt-5a and transforming growth factor-beta3 were expressed by both meningeal and PA6 cells, and the expression of Wnt-5a correlated with the DA neuron induction activity of these cells. Furthermore, the induction of DA neuron differentiation by PA6 cell-conditioned medium was reversed by addition of a Wnt-5a neutralizing antibody, whereas recombinant Wnt-5a promoted DA neuron induction when cells were cultured on Matrigel. These results indicate that meningeal cells can be used as feeders to induce DA neurons from ES cells, and that Wnt-5a plays an important role in DA neuron induction by SDIA.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	2
Volume Number	27
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-01-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Dopamine Embryonic Stem Cells Cytology Meninges Neurons Animals Cell Differentiation Physiology Cells, Cultured Coculture Techniques Methods Humans Mice Mice, Inbred C57bl Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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