NDLI: Synaptic sodium spikes trigger long-lasting depolarizations and slow calcium entry in rat olfactory bulb granule cells.

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Synaptic sodium spikes trigger long-lasting depolarizations and slow calcium entry in rat olfactory bulb granule cells.

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Synaptic sodium spikes trigger long-lasting depolarizations and slow calcium entry in rat olfactory bulb granule cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Egger, Veronica
Description	Country affiliation: Germany Author Affiliation: Egger V ( Institut für Physiologie der LMU, Pettenkoferstr. 12, 80336 München, Germany. V.Egger@lmu.de)
Abstract	In the mammalian olfactory bulb, axonless granule cells mediate self- and lateral inhibitory interactions between mitral/tufted cells via reciprocal dendrodendritic synapses. Synaptic output from granule cells occurs on both fast and slow timescales, allowing for multiple granule cell functions during olfactory processing. We find that granule cell sodium action potentials evoked by synaptic activation of the sensory input via mitral/tufted cells are followed by a long-lasting depolarization that is not observed after current-evoked action potentials or large excitatory postsynaptic potentials in the same cell. Using two-photon imaging in acute rat brain slices, we demonstrate that this prolonged electrical response is paralleled by an unusual, long-lasting postsynaptic calcium signal. We find that this slow synaptic Ca(2+) signal requires sequential activation of NMDA receptors, a nonselective cation conductance I(CAN) and T-type voltage-dependent Ca(2+) channels. Remarkably, T-type Ca(2+) channels are of critical importance for the 'globalization' of Ca(2+) transients. In individual active spines, the local synaptic Ca(2+) signal summates at least linearly with the global spike-mediated Ca(2+) signal. We suggest that this robust slow synaptic Ca(2+) signal triggers dendritic transmitter release and thus contributes to slow synaptic output of the granule cell. Therefore, the synaptic sodium spike signal could represent a special adaptation of granule cells to the wide range of temporal requirements for their dendritic output. Our findings demonstrate with respect to neuronal communication in general that action potentials evoked by somatic current injection may lack some of the information content of 'true' synaptically evoked spikes.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	8
Volume Number	27
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-04-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Calcium Metabolism Neurons Olfactory Bulb Sodium Synapses Synaptic Transmission Physiology Action Potentials Animals Calcium Channels, T-type Excitatory Postsynaptic Potentials Membrane Potentials Organ Culture Techniques Patch-clamp Techniques Rats Receptors, N-methyl-d-aspartate Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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