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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Palmer, Samantha J. Ng, Bernard Abugharbieh, Rafeef Eigenraam, Lisette McKeown, Martin J. |
| Description | Country affiliation: Canada Author Affiliation: Palmer SJ ( Pacific Parkinson's Research Center, Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada.) |
| Abstract | Motor symptoms of Parkinson's disease (PD) do not appear until the majority of dopaminergic cells in the substantia nigra pars compacta are lost, suggesting significant redundancy or compensation in the motor systems affected by PD. Using functional magnetic resonance imaging, we examined whether compensation in PD is manifested by changes in amplitude and/or spatial extent of activity within normal networks (active motor reserve) and/or newly recruited regions [novel area recruitment (NAR)]. Ten PD subjects off and on medication and 10 age-matched controls performed a visually guided sinusoidal force task at 0.25, 0.5 and 0.75 Hz. Regression was used to determine the combination of regions where activation amplitude scaled linearly with movement speed in controls. We then determined the activation of PD subjects in this network, as well as the corresponding PD network. To measure the spatial variance of activation, we used an invariant spatial feature approach. Control subjects monotonically increased activity within striato-thalamo-cortical and cerebello-thalamo-cortical regions with increasing movement speed. In PD subjects, the activity of this network at low speeds was similar to that in controls at higher speeds. Additionally, PD subjects off medication demonstrated NARs of the bilateral cerebellum and primary motor cortex, which were incompletely normalized by levodopa. Our results suggest that PD subjects tap into motor reserve, increase the spatial extent of activation and demonstrate NAR to maintain near-normal motor output. |
| File Format | HTM / HTML |
| ISSN | 0953816X |
| Issue Number | 11 |
| Volume Number | 29 |
| e-ISSN | 14609568 |
| Journal | European Journal of Neuroscience |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-06-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neuroscience Motor Cortex Physiology Motor Skills Parkinson Disease Physiopathology Psychomotor Performance Recruitment, Neurophysiological Spatial Behavior Adult Aged Female Humans Magnetic Resonance Imaging Methods Male Middle Aged Photic Stimulation Reaction Time Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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