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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Duncan, Marilyn J. Hester, James M. Hopper, Jason A. Franklin, Kathleen M. |
| Description | Country affiliation: United States Author Affiliation: Duncan MJ ( Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536, USA. marilyn.duncan@uky.edu) |
| Abstract | Age-related changes in circadian rhythms, including attenuation of photic phase shifts, are associated with changes in the central pacemaker in the suprachiasmatic nucleus (SCN). Aging decreases expression of mRNA for vasoactive intestinal peptide (VIP), a key neuropeptide for rhythm generation and photic phase shifts, and increases expression of serotonin transporters and 5-HT(1B) receptors, whose activation inhibits these phase shifts. Here we describe studies in hamsters showing that aging decreases SCN expression of mRNA for gastrin-releasing peptide, which also modulates photic phase resetting. Because serotonin innervation trophically supports SCN VIP mRNA expression, and serotonin transporters decrease extracellular serotonin, we predicted that chronic administration of the serotonin-selective reuptake inhibitor, fluoxetine, would attenuate the age-related changes in SCN VIP mRNA expression and 5-HT(1B) receptors. In situ hybridization studies showed that fluoxetine treatment does not alter SCN VIP mRNA expression, in either age group, at zeitgeber time (ZT)6 or 13 (ZT12 corresponds to lights off). However, receptor autoradiographic studies showed that fluoxetine prevents the age-related increase in SCN 5-HT(1B) receptors at ZT6, and decreases SCN 5-HT(1B) receptors in both ages at ZT13. Therefore, aging effects on SCN VIP mRNA and SCN 5-HT(1B) receptors are differentially regulated; the age-related increase in serotonin transporter sites mediates the latter but not the former. The studies also showed that aging and chronic fluoxetine treatment decrease total daily wheel running without altering the phase of the circadian wheel running rhythm, in contrast to previous reports of phase resetting by acute fluoxetine treatment. |
| File Format | HTM / HTML |
| ISSN | 0953816X |
| e-ISSN | 14609568 |
| DOI | 10.1111/j.1460-9568.2010.07186.x |
| Journal | European Journal of Neuroscience |
| Issue Number | 9 |
| Volume Number | 31 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-05-01 |
| Publisher Place | France |
| Access Restriction | Open |
| Subject Keyword | Discipline Neuroscience Aging Physiology Circadian Rhythm Drug Effects Fluoxetine Pharmacology Serotonin Uptake Inhibitors Suprachiasmatic Nucleus Animals Cricetinae Administration & Dosage Gastrin-releasing Peptide Metabolism Motor Activity Neuropeptides Photoperiod Rna, Messenger Receptor, Serotonin, 5-ht1b Serotonin Plasma Membrane Transport Proteins Vasoactive Intestinal Peptide Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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