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Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ventura-Silva, Ana P. Pêgo, José M. Sousa, João C. Marques, Ana R. Rodrigues, Ana J. Marques, Fernanda Cerqueira, João J. Almeida, Osborne F. X. Sousa, Nuno
Description	Country affiliation: Portugal Author Affiliation: Ventura-Silva AP ( Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.)
Abstract	The bed nucleus of the stria terminalis (BNST) is critically implicated in anxiety behavior and control of the hypothalamus-pituitary-adrenal axis. Having previously shown that chronic stress triggers dendritic/synaptic remodeling in specific nuclei of the BNST, we characterised the pattern of activation of neurons within different regions of the BNST under basal conditions and after an anxiogenic stimulus in control and stressed rats. Under basal conditions, stressed, but not control, animals displayed increased cFOS expression in the dorsomedial nucleus and decreased activation of the principal nucleus. This pattern resembled that observed in controls that had been exposed to the anxiogenic stimulus. Subsequent analysis of various BNST subnuclei revealed differential patterns of gene expression in controls and stressed animals. We found decreased levels of corticotropin-releasing hormone 1 receptor mRNA expression in the dorsomedial and fusiform nuclei, and a global increase in the levels of corticotropin-releasing hormone 2 receptor in the principal nucleus. In addition, we found subnuclei-specific increases in GABA(A) and NR2B receptors in stressed animals, which suggest changes in the GABAergic and glutamergic innervation of the BNST. Importantly, these findings were associated with increased anxiety-like behavior and impaired control of the hypothalamus-pituitary-adrenal axis in stressed animals. In summary, these data reveal that chronic stress shifts the pattern of response of the BNST to an anxiogenic mode and provide new information on the underlying mechanisms of the stress-induced hypercorticalism and hyperanxious status.
File Format	HTM / HTML
ISSN	0953816X
Issue Number	10
Volume Number	36
e-ISSN	14609568
Journal	European Journal of Neuroscience
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-11-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neuroscience Anxiety Metabolism Septal Nuclei Stress, Psychological Animals Psychology Gene Expression Male Maze Learning Proto-oncogene Proteins C-fos Genetics Rna, Messenger Biosynthesis Rats Rats, Wistar Receptors, Corticotropin-releasing Hormone Receptors, Gaba-a Receptors, N-methyl-d-aspartate Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode.

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