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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Cong Li, Xue-Nan Xiang, Li-Run Qin, Lei Lin, Jia Li, Jin-Long |
| Description | Author Affiliation: Zhang C ( College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China.); Li XN ( College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China.); Xiang LR ( College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China.); Qin L ( College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China); Lin J ( College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China.); Li JL ( College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China. Electronic address: Jinlongli@neau.edu.cn.) |
| Abstract | The bioaccumulation and environmental persistence of atrazine (ATZ) poses a severe hazard to animal ecosystem. Quail has strong sensitivity to environmental pollutant, thus it is one of the most important ecological pollution indicator. However, true proof for the effects of ATZ exposure on the liver of quails is lacking. To evaluate the liver injury and the role of Nrf2-mediated defense responses during ATZ exposure, male quails were treated with ATZ (0, 50, 250 and 500mg/kg) by oral gavage for 45 days. Histopathological and ultrastructural changes, oxidative stress indices, apoptosis-related factors and Nrf2 pathway were detected. ATZ caused irreparable mitochondrial damage and destroyed morphophysiological integrity of the quail liver. Lower level ATZ (<250mg/kg) activated Nrf2 signaling pathway to protect liver against oxidative stress and apoptosis via enhancing antioxidative activity. Higher level ATZ (>500mg/kg) induced oxidative stress and apoptosis through decrease of non-enzymatic antioxidant, antioxidant enzymes and anti-apoptosis factors and increase of apoptosis factors expressions. Taken together, our results suggested that ATZ-induced hepatotoxicity in quails was associated with blocking Nrf2-mediated defense response. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Journal | Ecotoxicology and Environmental Safety |
| Volume Number | 137 |
| e-ISSN | 10902414 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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