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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Yuanchuan Zhong, Hongxiu Wang, Chonggang Gao, Dongxu Zhou, Yulin Zuo, Zhenghong |
| Description | Country affiliation: China Author Affiliation: Wang Y ( State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.); Zhong H ( Prenatal Diagnosis Center of Xiamen, Maternal and Child Health Hospital of Xiamen, Xiamen 361003, China.); Wang C ( State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China); Gao D ( State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.); Zhou Y ( Prenatal Diagnosis Center of Xiamen, Maternal and Child Health Hospital of Xiamen, Xiamen 361003, China. Electronic address: zhou_yulin@126.com.); Zuo Z ( State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China) |
| Abstract | Autism spectrum disorder (ASD) is a serious debilitating mental illness with complex symptoms and multi-factorial pathogenesis. Although the pathogenesis of ASD remains unclear, etiology is thought to involve complex, multigenic interactions and possible environmental contributions. In the present study, we used zebrafish (Danio rerio) as a model to investigate whether maternal exposure to the water soluble fraction of crude oil (WSF, 5µg/L), lead (Pb, 20µg/L) and their mixture (5 µg/L WSF+20 µg/L Pb) could induce autism-like behavior in larvae. Our results showed that isolated and combined WSF/Pb exposure altered the behavioral pattern of fish swimming. WSF significantly increased anxiety and locomotor activity, decreased repetitive behavior in the open field test, and reduced the level of serotonin. However, co-exposure to WSF/Pb decreased behavioral activity and shoaling behavior, and increased cycle swimming and edge preference. Significant changes in the expression level of the multiple genes potentially critical for regulating environmental factor induced autism-like behavior were found. A gene network regulating ASD disturbed by WSF/Pb exposure was established using computational analysis. The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating WSF/Pb mediated ASD. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Journal | Ecotoxicology and Environmental Safety |
| Volume Number | 134P1 |
| e-ISSN | 10902414 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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