| Author |
Qi, Zhihong Zhang, Lin Chen, Yu Ma, Xinming Gao, Xuehui Du, Juan Zhang, Fang Cheng, Xinqi Cui, Wei |
| Description |
Country affiliation: China Author Affiliation: Qi Z ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Zhang L ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Chen Y ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Ma X ( Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China.); Gao X ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Du J ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Zhang F ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Cheng X ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.); Cui W ( Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address: wendycuiwei@sina.cn.) |
| Abstract |
BACKGROUND: We sought to identify biological variations in the following tumor markers: pepsinogen I (PGI), pepsinogen II (PGII), carbohydrate antigen 724 (CA724), neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199). METHODS: Serum samples were collected from 20 healthy Chinese individuals over 5 days. Samples were then screened for the presence of the seven aforementioned tumor markers. Within-individual coefficient of variation (CVI), between-individual coefficient of variation (CVG), confidence interval (CI) of biological variations, index of individuality (II), and the reference change value (RCV) of the seven tumor markers were calculated. RESULTS: Of the 7 tumor markers, index of individuality was all <1.0. ProGRP showed the lowest CVI and CVG, at 4.75% (CI: 3.96%-5.94%) and 16.42% (CI: 12.32%-24.61%), respectively. The 95% and 99% RCVs for ProGRP were 14.68 and 19.32, respectively, and were the lowest of the markers. In contrast, the CVI and CVG for CA724 were the highest, at 16.06% (CI: 13.83%-19.17%) and 96.95% (CI: 73.73%-141.59%), respectively. The 95% and 99% RCVs for CA724 were the highest, at 45.89 and 60.41, respectively. CONCLUSION: Our findings provide additional information regarding the biological variation of tumor markers, and could be applied in a clinical setting. |
