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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Ying Lin, Yisheng Lin, Haijuan Xiao, Jingrong Jiang, Li Chen, Cen Zhuo, Xiaofu Huang, Wenhua Zeng, Jia Dettke, Markus |
| Description | Author Affiliation: Chen Y ( Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China); Lin Y ( Quanzhou Blood Center, Quanzhou 362018, China.); Lin H ( Fujian Provincial Blood Center, Fuzhou 350004, China.); Xiao J ( Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China.); Jiang L ( Fujian Provincial Blood Center, Fuzhou 350004, China.); Chen C ( Fujian Provincial Blood Center, Fuzhou 350004, China.); Zhuo X ( Fujian Provincial Blood Center, Fuzhou 350004, China.); Huang W ( Fujian Provincial Blood Center, Fuzhou 350004, China.); Zeng J ( Fujian Provincial Blood Center, Fuzhou 350004, China.); Dettke M ( Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna 1090, Austria.) |
| Abstract | BACKGROUND: We explored the effects of repeated plateletpheresis on the platelet P-selectin expression and soluble P-selectin (sP-selectin) concentrations in platelet donors. METHODS: Totally 289 platelet donors and 97 first-time whole blood (WB) donors were enrolled from the blood donor registry at the Fujian provincial blood center, China. The accumulative numbers of plateletpheresis in the last 2 y for participants were recorded, and the basal concentrations of platelet count, sP-selectin and total platelet P-selectin (pP-selectin) were determined. RESULTS: Platelet donors had significantly higher basal concentrations of sP-selectin compared to WB donors (24.12±7.33ng/mL vs. 20.74±5.44ng/mL, P<0.0001), with no difference in platelet count and pP-selectin concentrations. Increased numbers of platelet donation were correlated with a steady increase of sP-selectin (r=0.18, P=0.002). Multivariate regression analysis identified that the frequency of plateletpheresis is an independent factor for the rise of the sP-selectin concentration (t=2.64, P=0.009) while no association was found for pP-selectin and platelet count. CONCLUSIONS: Repeated plateletpheresis could result in an increased basal concentration of sP-selectin in blood donors whereas not an alteration in the concentrations of total platelet P-selectin. It remains to be determined whether this might be a consequence of endothelial activation or platelet activation or some other phenomenon. |
| File Format | HTM / HTML |
| ISSN | 00098981 |
| Journal | Clinica Chimica Acta |
| Volume Number | 458 |
| e-ISSN | 18733492 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry Biochemistry |
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