NDLI: Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.

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Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Diorio, Caroline Brisson, Jacques Bérubé, Sylvie Pollak, Michael
Description	Country affiliation: Canada Author Affiliation: Diorio C ( Breast Cancer Functional Genomics Group and McGill Centre for Bioinformatics, McGill University, Montreal, QC, Canada. caroline.diorio@uresp.ulaval.ca)
Abstract	The insulin-like growth factor (IGF) pathway is believed to play a role in carcinogenesis of the mammary gland. Single nucleotide polymorphisms (SNPs) of IGF-I, IGF-binding protein-3 (IGFBP-3), IGF receptor 1, insulin receptor substrate 1, and phosphoinositide-3-kinase, catalytic, beta polypeptide genes, which are members of the IGF pathway, have been associated with risk of common cancers, breast density, and/or IGF levels but results remain inconclusive. Thus, we evaluated the association of 11 targeted IGF pathway SNPs with circulating IGF levels and mammographic breast density. Among 741 white premenopausal women, blood samples were collected at time of screening mammography, and plasma IGF-I and IGFBP-3 levels were measured by ELISA. Percent and absolute breast density were estimated using a computer-assisted method. Multivariate linear models were used to examine the associations. Women carrying increasing number of copies of the rare allele of IGF-I rs1520220 and rs6220 SNPs had increased percent breast density (P(trend) = 0.04 and 0.06, respectively). Carriers of increasing number of copies of the rare allele of phosphoinositide-3-kinase, catalytic, beta polypeptide rs361072 SNP had decreased percent (P(trend) = 0.04) and absolute (P(trend) = 0.02) breast density. An association of insulin receptor substrate 1 rs1801278 SNP with absolute density (P(trend) = 0.03) was also observed. All four IGFBP-3 SNPs (including rs2854744) were associated with IGF-I and IGFBP-3 levels. This study shows that several components of the IGF pathway are associated with breast density or IGF levels. Our findings provide additional support for the idea that several components of the IGF pathway may affect breast cancer risk and that this effect on breast cancer development may be mediated, at least in part, through its influence on the morphogenesis of breast tissue.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	4
Volume Number	17
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2008-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Breast Neoplasms Genetics Breast Physiology Insulin-like Growth Factor Binding Protein 3 Insulin-like Growth Factor I Polymorphism, Genetic Anatomy & Histology Blood Etiology Genotype Linear Models Mammography Polymorphism, Single Nucleotide Premenopause Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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