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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kalmyrzaev, Bolot Pharoah, Paul D. P. Easton, Douglas F. Ponder, Bruce A. J. Dunning, Alison M. |
| Spatial Coverage | England |
| Description | Author Affiliation: Kalmyrzaev B ( University of Cambridge Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN United Kingdom. bolot.kalmyrzaev@srl.cam.ac.uk) |
| Abstract | A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint analysis of two small case-control studies. We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European case-control study and find no association of any of them with risk of breast cancer: rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6]. |
| File Format | HTM / HTML |
| ISSN | 10559965 |
| e-ISSN | 15387755 |
| Journal | Cancer Epidemiology Biomarkers & Prevention |
| Issue Number | 12 |
| Volume Number | 17 |
| Language | English |
| Publisher | American Association for Cancer Research |
| Publisher Date | 2008-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cancer epidemiology Antigens, Cd44 Genetics Breast Neoplasms Extracellular Matrix Proteins Polymorphism, Single Nucleotide Case-control Studies Chi-square Distribution False Positive Reactions Genotype Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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