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Common variation in Nemo-like kinase is associated with risk of ovarian cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stevens, Kristen N. Kelemen, Linda E. Wang, Xianshu Fridley, Brooke L. Vierkant, Robert A. Fredericksen, Zachary Armasu, Sebastian M. Tsai, Ya-Yu Berchuck, Andrew Narod, Steven A. Phelan, Catherine M. Sutphen, Rebecca Birrer, Michael J. Schildkraut, Joellen M. Sellers, Thomas A. Goode, Ellen L. Couch, Fergus J.
Organization	Ovarian Cancer Association Consortium
Description	Country affiliation: United States Author Affiliation: Stevens KN ( Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.)
Abstract	BACKGROUND: Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined. METHODS: We measured associations between 397 single nucleotide polymorphisms (SNPs) from 67 mitotic kinases and invasive epithelial ovarian cancer risk in two case-control studies (n = 671 cases; n = 939 controls). Thirty-six candidate SNPs (P < 0.05) were assessed in a replication analysis consisting of three additional studies (n = 1,094 cases; n = 829 controls). RESULTS: In initial analysis, thirty-six SNPs were suggestive of association with risk of serous ovarian cancer, all subtypes of ovarian cancer, or both (P < 0.05). Replication analyses suggested an association between rs2125846 in the Nemo-like kinase (NLK) gene and ovarian cancer (serous OR = 1.36, 95% CI: 1.11-1.67, P = 1.77 × 10(-3); all subtypes OR = 1.30, 95% CI: 1.08-1.56, P = 2.97 × 10(-3)). Furthermore, rs2125846 was associated with risk in the combined discovery and replication sets (serous OR = 1.33, 95% CI: 1.15-1.54; all subtypes OR = 1.27, 95% CI: 1.12-1.45). CONCLUSIONS: Variation in NLK may be associated with risk of invasive epithelial ovarian cancer. Further studies are needed to confirm and understand the biologic relationship between this mitotic kinase and ovarian cancer risk. IMPACT: An association between SNPs in NLK and ovarian cancer may provide biologic insight into the development of this disease.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-11-0797
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	3
Volume Number	21
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Tumor Markers, Biological Genetics Cystadenocarcinoma, Serous Intracellular Signaling Peptides And Proteins Mitosis Ovarian Neoplasms Polymorphism, Single Nucleotide Protein-serine-threonine Kinases Blood Case-control Studies Dna, Neoplasm Neoplasm Invasiveness Polymerase Chain Reaction Prognosis Risk Factors Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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