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Plasma sphingolipids and lung cancer: A population-based, nested case-control study

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alberg, Anthony J. Armeson, Kent Pierce, Jason S. Bielawski, Jacek Bielawska, Alicja Visvanathan, Kala Hill, Elizabeth G. Ogretmen, Besim
Spatial Coverage	Maryland
Description	Country affiliation: United States Author Affiliation: Alberg AJ ( Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA. alberg@musc.edu)
Abstract	BACKGROUND: Sphingosine-1-phosphate (S1P) and ceramides are bioactive signaling sphingolipids that regulate pathways that are central to cancer pathogenesis. METHODS: A nested case-control study was implemented to test whether prediagnostic circulating concentrations of S1P and ceramides were associated with future lung cancer risk. In the community-based CLUE II cohort study in Washington County, Maryland, the study consisted of 100 incident lung cancer cases, each matched to two cancer-free controls on age, sex, race, and cigarette smoking status. Plasma stored at -70°C at the beginning of follow-up in 1989 was assayed for sphingolipids using liquid chromatography/tandem mass spectrometry methodology (LC/MS-MS). RESULTS: Compared with controls, geometric mean plasma concentrations of S1P and total ceramides were 2.9% (P = 0.10) and 5.1% (P = 0.02), respectively, greater in lung cancer cases. For S1P, the ORs and 95% confidence intervals (CI) for lung cancer risk were 2.7 (1.2-5.9), 2.7 (1.1-6.4), and 1.9 (0.8-4.5) for the second, third, and highest fourth, respectively, compared with the lowest fourth (overall P = 0.006). Compared with those with total ceramide concentrations in the lowest fourth, the ORs (and 95% CI) for lung cancer risk were 1.6 (0.7-3.3), 1.5 (0.7-3.4), and 2.1 (0.9-4.7) for the second, third, and highest fourth, respectively (P(trend) = 0.01). CONCLUSIONS: Higher concentrations of S1P and total ceramide in plasma were associated with increased future risk of lung cancer. IMPACT: These novel findings suggest that perturbation of sphingolipid metabolism and S1P generation may either contribute to the etiology of lung cancer or be a marker of latent lung cancer.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-12-1424
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	8
Volume Number	22
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Tumor Markers, Biological Blood Ceramides Lung Neoplasms Lysophospholipids Sphingolipids Sphingosine Analogs & Derivatives Case-control Studies Cohort Studies Epidemiology Maryland Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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