| Author |
Park, S. Lani Caberto, Christian P. Lin, Yi Goodloe, Robert J. Dumitrescu, Logan Love, Shelly-Ann Matise, Tara C. Hindorff, Lucia A. Fowke, Jay H. Schumacher, Fredrick R. Beebe-Dimmer, Jennifer Chen, Chu Hou, Lifang Thomas, Fridtjof Deelman, Ewa Han, Ying Peters, Ulrike North, Kari E. Heiss, Gerardo Crawford, Dana C. Haiman, Christopher A. Wilkens, Lynne R. Bush, William S. Kooperberg, Charles Cheng, Iona Le Marchand, Loïc |
| Description |
Author Affiliation: Park SL ( Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California. sungship@usc.edu.); Caberto CP ( Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.); Lin Y ( Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.); Goodloe RJ ( Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee.); Dumitrescu L ( Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.); Love SA ( Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.); Matise TC ( Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey.); Hindorff LA ( Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.); Fowke JH ( Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee.); Schumacher FR ( Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.); Beebe-Dimmer J ( School of Medicine, Wayne State University, Detroit, Michigan. Karmanos Cancer Institute, Detroit, Michigan.); Chen C ( Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.); Hou L ( Department of Preventative Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.); Thomas F ( Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.); Deelman E ( USC Information Sciences Institute, University of Southern California, Marina del Rey, California.); Han Y ( Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.); Peters U ( Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.); North KE ( Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina. Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, California.); Heiss G ( Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.); Crawford DC ( Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio.); Haiman CA ( Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.); Wilkens LR ( Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.); Bush WS ( Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio.); Kooperberg C ( Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.); Cheng I ( Cancer Prevention Institute of California, Fremont, California.); Le Marchand L ( Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.) |
| Abstract |
BACKGROUND: Multiple primary cancers account for approximately 16% of all incident cancers in the United States. Although genome-wide association studies (GWAS) have identified many common genetic variants associated with various cancer sites, no study has examined the association of these genetic variants with risk of multiple primary cancers (MPC). METHODS: As part of the National Human Genome Research Institute (NHGRI) Population Architecture using Genomics and Epidemiology (PAGE) study, we used data from the Multiethnic Cohort (MEC) and Women's Health Initiative (WHI). Incident MPC (IMPC) cases (n = 1,385) were defined as participants diagnosed with more than one incident cancer after cohort entry. Participants diagnosed with only one incident cancer after cohort entry with follow-up equal to or longer than IMPC cases served as controls (single-index cancer controls; n = 9,626). Fixed-effects meta-analyses of unconditional logistic regression analyses were used to evaluate the associations between 188 cancer risk variants and IMPC risk. To account for multiple comparisons, we used the false-positive report probability (FPRP) to determine statistical significance. RESULTS: A nicotine dependence-associated and lung cancer variant, CHRNA3 rs578776 [OR, 1.16; 95% confidence interval (CI), 1.05-1.26; P = 0.004], and two breast cancer variants, EMBP1 rs11249433 and TOX3 rs3803662 (OR, 1.16; 95% CI, 1.04-1.28; P = 0.005 and OR, 1.13; 95% CI, 1.03-1.23; P = 0.006), were significantly associated with risk of IMPC. The associations for rs578776 and rs11249433 remained (P < 0.05) after removing subjects who had lung or breast cancers, respectively (P ≤ 0.046). These associations did not show significant heterogeneity by smoking status (Pheterogeneity ≥ 0.53). CONCLUSIONS: Our study has identified rs578776 and rs11249433 as risk variants for IMPC. IMPACT: These findings may help to identify genetic regions associated with IMPC risk. |
