NDLI: Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation.

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Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mowafi, H. A. Aldossary, N. Ismail, S. A. Alqahtani, J.
Description	Country affiliation: Saudi Arabia Author Affiliation: Mowafi HA ( Department of Anaesthesiology, Faculty of Medicine, King Faisal University, Saudi Arabia. hany_mowafi@hotmail.com)
Abstract	BACKGROUND: Succinylcholine is still recommended for some situations in open globe injuries. However, the use of succinylcholine is associated with an increase in intraocular pressure (IOP). This may be deleterious in open globe injuries. No method has previously been shown to abolish completely this rise in the IOP. We investigated whether dexmedetomidine, an alpha-2 agonist, could attenuate this increase in the IOP after succinylcholine and intubation. METHODS: Forty patients with no pre-existing eye disease undergoing general anaesthesia were randomly premedicated by i.v. dexmedetomidine 0.6 microg kg(-1), or saline. Heart rate (HR), mean arterial pressure (MAP), and IOP (using Schioetz tonometer) were measured before, after the premedication, after thiopental, after succinylcholine, immediately after intubation, and then every 2 min for 6 min. RESULTS: Succinylcholine and intubation increased IOP in both groups. However, in the dexmedetomidine group, the IOP rise was not different from the baseline value (P=0.65) and was significantly lower than in the saline group (P=0.003). After intubation, the MAP in the control group was higher than that in the dexmedetomidine group (P=0.041) and exceeded the baseline value (P<0.001). The HR also showed less fluctuation in the dexmedetomidine group than in the saline group. CONCLUSIONS: We conclude that dexmedetomidine could be a beneficial premedication in open globe injuries.
File Format	HTM / HTML
ISSN	00070912
e-ISSN	14716771
Journal	British Journal of Anaesthesia
Issue Number	4
Volume Number	100
Language	English
Publisher	Oxford University Press
Publisher Date	2008-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Anesthesiology Dexmedetomidine Therapeutic Use Intubation, Intratracheal Adverse Effects Neuromuscular Depolarizing Agents Ocular Hypertension Prevention & Control Succinylcholine Adrenergic Alpha-agonists Pharmacology Blood Pressure Drug Effects Heart Rate Hypnotics And Sedatives Intraocular Pressure Antagonists & Inhibitors Etiology Physiopathology Premedication Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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