NDLI: Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium.

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Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kassam, S. I. Lu, C. Buckley, N. Gao, Y. J. Lee, R. M. K. W.
Description	Country affiliation: Canada Author Affiliation: Kassam SI ( Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.)
Abstract	BACKGROUND: Thiopental induces relaxation of vascular smooth muscle cells through its direct and/or indirect vasodilator effects. The perivascular adipose tissue (PVAT) and the endothelium are known to attenuate vascular contraction, and we have recently reported that PVAT potentiates the relaxation effect of propofol through endothelium-dependent and -independent mechanisms. Here, we studied the mechanisms of thiopental-induced vascular responses in relation to the involvement of PVAT and endothelium. METHODS: Thoracic aortic rings from male Wistar rats were prepared with or without PVAT (PVAT+ and PVAT-) and with an intact endothelium (E+) or with the endothelium removed (E-) for functional studies. The contraction and relaxation responses of these vessels to thiopental in the presence of agonists and various receptor antagonists and channel blockers were studied. RESULTS: In vessels pre-contracted with phenylephrine or KCl, thiopental-induced relaxation was highest in vessels denuded of both PVAT and the endothelium. PVAT attenuated the relaxation response to thiopental, and this attenuation effect was reduced by both angiotensin II (Ang II) type 1 receptor antagonists CV-11974 (2-n-butyl-4-choloro-5-hydroxymethyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-methyl]-imidazole) or losartan and the angiotensin-converting enzyme inhibitor enalaprilat. Thiopental at high concentration (3 × 10(-3) M) caused a contraction through an endothelin-dependent mechanism. CONCLUSIONS: Thiopental induced relaxation in rat aorta through an endothelium-independent pathway and the presence of PVAT, endothelium, or both attenuated this relaxation response through Ang II-dependent and endothelin-dependent mechanisms, respectively.
File Format	HTM / HTML
ISSN	00070912
e-ISSN	14716771
Journal	British Journal of Anaesthesia
Issue Number	2
Volume Number	109
Language	English
Publisher	Oxford University Press
Publisher Date	2012-08-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Anesthesiology Adipose Tissue Physiology Anesthetics, Intravenous Pharmacology Endothelium, Vascular Thiopental Vasodilation Drug Effects Angiotensin Ii Animals Aorta, Thoracic Endothelins Guanylate Cyclase Phenylephrine Potassium Channels Potassium Chloride Rats, Wistar Tissue Culture Techniques Vasoconstriction Vasodilator Agents Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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