NDLI: Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate

Please wait, while we are loading the content...

Influence of intensive care treatment on the protein binding of sufentanil and hydromorphone during pain therapy in postoperative cardiac surgery patients.

Accuracy and precision of the ultrasound cardiac output monitor (USCOM 1A) in pregnancy: comparison with three-dimensional transthoracic echocardiography.

Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate.

Selective decontamination of the digestive tract: time to implement it in all UK intensive care units? Maybe not yet.

Generalizability of anaesthesia study populations.

5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: protocol, methods, and analysis of data.

5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: patient experiences, human factors, sedation, consent, and medicolegal issues.

5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

NAP5: the tip of the iceberg, or all we need to know?

NAP5: intraoperative awareness detected, and undetected.

Personal and medicolegal implications of awareness.

The state of UK anaesthesia: a survey of National Health Service activity in 2013.

In-plane ultrasound-guided needle insertion ALONG or ACROSS the visual axis hand positions.

Finding the bulging edge: a modified shamrock lumbar plexus block in average-weight patients.

Trachway in assistance of nasotracheal intubation with a preformed nasotracheal tube in patients undergoing oral maxillofacial surgery.

ß-Blockers and cardiac protection.

Year: 2014 Volume: 113 Issue: 3

Year: 2014 Volume: 113 Issue: 2

Year: 2014 Volume: 113 Issue: Supplementary 2

Year: 2014 Volume: 113 Issue: 1

Year: 2014 Volume: 113 Issue: Supplementary 1

Year: 2014 Volume: 112

Year: 2013 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2012 Volume: 108

Year: 2011 Volume: 107

Year: 2011 Volume: 106

Year: 2010 Volume: 105

Year: 2010 Volume: 104

Year: 2009 Volume: 103

Year: 2009 Volume: 102

Year: 2008 Volume: 101

Year: 2008 Volume: 100

Year: 2007 Volume: 98

Year: 2006 Volume: 96

Year: 2005 Volume: 95

Year: 2005 Volume: 94

Year: 2004 Volume: 93

Year: 2003 Volume: 91

Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhong, T. Qing, Q. J. Yang, Y. Zou, W. Y. Ye, Z. Yan, J. Q. Guo, Q. L.
Description	Author Affiliation: Zhong T ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China.); Qing QJ ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China.); Yang Y ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China.); Zou WY ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China.); Ye Z ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China.); Yan JQ ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China.); Guo QL ( Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, PR China guoqulian@gmail.com.)
Abstract	Background Isoflurane produces amnesia in mice during contextual fear conditioning (CFC) trials. Histone acetylation is a form of chromatin modification involved in the transcriptional regulation underlying memory formation. We investigated whether isoflurane-induced repression of contextual fear memory is related to altered histone acetylation in the hippocampus, and whether it can be rescued by the histone deacetylases inhibitor sodium butyrate (SB). Methods Adult C57BL/6 mice were chronically given intraperitoneal injections of SB or vehicle for 28 days. Immediately before CFC training, the mice were exposed to isoflurane or air for 30 min and CFC testing was performed the next day. Hippocampal histone acetylation was analysed 1 h after CFC training. c-Fos, an immediate early gene (IEG) suggested to participate in learning and memory formation, was also investigated at the same timepoint. Results Mice exposed to isoflurane showed a reduction in freezing time during the CFC test. These mice also exhibited reduced hippocampal H3K14, H4K5, and H4K12 acetylation 1 h after CFC training, and also decreased c-Fos expression. All of these changes were attenuated in isoflurane-exposed mice that were chronically treated with SB. Conclusions Isoflurane suppresses histone acetylation and down-regulates c-Fos gene expression in CA1 of the hippocampus after CFC training. These changes are associated with isoflurane-induced amnesia. The HDAC inhibitor SB prevented repressed contextual fear memory, presumably by promoting histone acetylation and histone acetylation-mediated gene expression in response to CFC training.
File Format	HTM / HTML
ISSN	00070912
e-ISSN	14716771
Journal	British Journal of Anaesthesia
Issue Number	4
Volume Number	113
Language	English
Publisher	Oxford University Press
Publisher Date	2014-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Anesthesiology Anesthetics, Inhalation Pharmacology Butyric Acid Drug Effects Histone Deacetylase Inhibitors Histones Metabolism Isoflurane Memory Acetylation Animals Behavior, Animal Blotting, Western Brain Chemistry Conditioning (psychology) Epigenesis, Genetic Gene Expression Hippocampus Immunohistochemistry Physiology Mice Mice, Inbred C57bl Proto-oncogene Proteins C-fos Biosynthesis Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Altered histone acetylation is associated with age-dependent memory impairment in mice.

Isoflurane causes neocortical but not hippocampal-dependent memory impairment in mice.

The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference.

Inhibition of Histone Deacetylase by Butyrate Protects Rat Liver from Ischemic Reperfusion Injury

Epigenetics. A role for epigenetics in cognition.

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.

Neuroscience. Epigenetics and cognitive aging.

Histone acetylation: molecular mnemonics on the chromatin.

Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate

Similar Documents

Altered histone acetylation is associated with age-dependent memory impairment in mice.

Isoflurane causes neocortical but not hippocampal-dependent memory impairment in mice.

The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference.

Inhibition of Histone Deacetylase by Butyrate Protects Rat Liver from Ischemic Reperfusion Injury

Epigenetics. A role for epigenetics in cognition.

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.

Neuroscience. Epigenetics and cognitive aging.

Histone acetylation: molecular mnemonics on the chromatin.

Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate