NDLI: Mortality in mothers after perinatal loss: a population-based follow-up study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hvidtjørn, D. Wu, C. Schendel, D. Thorlund Parner, E. Brink Henriksen, T.
Description	Country affiliation: Denmark Author Affiliation: Hvidtjørn D ( Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.); Wu C ( Department of Obstetrics and Gynaecology, Aarhus University Hospital Skejby, Aarhus, Denmark.); Schendel D ( Section for Epidemiology, Department of Public Health, University of Aarhus, Aarhus, Denmark.); Thorlund Parner E ( Section for Epidemiology, Department of Public Health, University of Aarhus, Aarhus, Denmark.); Brink Henriksen T ( National Centre for Register-based Research, Department of Economics and Business, University of Aarhus, Aarhus, Denmark.)
Abstract	OBJECTIVE: To assess whether mothers who lost a child from stillbirth or in the first week of life have an increased overall mortality and cause-specific mortality. DESIGN: A population based follow-up study. SETTING: Data from Danish national registers. POPULATION: All mothers in Denmark were included in the cohort at time of their first delivery from 1 January 1980 to 31 December 2008 and followed until 31 December 2009 or death, whichever came first. METHODS: The association between perinatal loss and total and cause-specific mortality in mothers was estimated with hazard ratios (HR) and 95% confidence intervals (95% CI) calculated using Cox proportional hazards regression analyses. MAIN OUTCOME MEASURES: Overall mortality and cause-specific mortality. RESULTS: During the follow-up period, 838,331 mothers in the cohort gave birth to one or more children and 7690 mothers (0.92%) experienced a perinatal loss. During follow-up, 8883 mothers (1.06%) died. There was an increased overall mortality for mothers who experienced a perinatal loss adjusted for maternal age and educational level, hazard ratio (HR) 1.83 [95% confidence interval (CI) 1.55-2.17]. The strongest association was seen in mortality from cardiovascular diseases (CVD) with an HR of 2.29 (95% CI 1.48-3.52) adjusted for CVD at time of delivery. We found no association between a perinatal loss and mortality from traumatic causes. CONCLUSIONS: Mothers who experience a perinatal loss have an increased mortality, especially from CVD.
File Format	HTM / HTML
ISSN	14700328
e-ISSN	14710528
Journal	BJOG: An International Journal of Obstetrics & Gynaecology
Issue Number	3
Volume Number	123
Language	English
Publisher	Wiley
Publisher Date	2016-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Obstetrics Discipline Gynecology Maternal Mortality Perinatal Death Cause Of Death Cohort Studies Infant, Newborn
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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