NDLI: Control of Hypertension In Pregnancy Study randomised controlled trial-are the results dependent on the choice of labetalol or methyldopa?

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Control of Hypertension In Pregnancy Study randomised controlled trial-are the results dependent on the choice of labetalol or methyldopa?

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Control of Hypertension In Pregnancy Study randomised controlled trial-are the results dependent on the choice of labetalol or methyldopa?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Magee, L. A. Von Dadelszen, P. Singer, J. Lee, T. Rey, E. Ross, S. Asztalos, E. Murphy, K. E. Menzies, J. Sanchez, J. Gafni, A. Gruslin, A. Helewa, M. Hutton, E. Koren, G. Lee, S. K. Logan, A. G. Ganzevoort, J. W. Welch, R. Thornton, J. G. Moutquin, J-M
Description	Country affiliation: Canada Author Affiliation: Magee LA ( Medicine, University of British Columbia, Vancouver, BC, Canada.); von Dadelszen P ( School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.); Lee T ( Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada.); Rey E ( School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.); Ross S ( School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.); Asztalos E ( Centre for Health Evaluation and Outcome Sciences (CHÉOS), Providence Health Care Research Institute, UBC, Vancouver, BC, Canada.); Murphy KE ( Centre for Health Evaluation and Outcome Sciences (CHÉOS), Providence Health Care Research Institute, UBC, Vancouver, BC, Canada.); Menzies J ( Medicine and Obstetrics and Gynaecology, University of Montreal, Montreal, QC, Canada.); Sanchez J ( Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada.); Gafni A ( Paediatrics, University of Toronto, Toronto, ON, Canada.); Gruslin A ( Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.); Helewa M ( The Centre for Mother, Infant and Child Research, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.); Hutton E ( Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.); Koren G ( The Centre for Mother, Infant and Child Research, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.); Lee SK ( Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada.); Logan AG ( The Centre for Mother, Infant and Child Research, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.); Ganzevoort JW ( Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.); Welch R ( Obstetrics and Gynaecology, University of Ottawa, Ottawa, ON, Canada.); Thornton JG ( Obstetrics and Gynaecology, University of Manitoba, Winnipeg, MB, Canada.); Moutquin JM ( Obstetrics and Gynaecology, McMaster University, Hamilton, ON, Canada.)
Abstract	OBJECTIVE: To determine whether the difference in outcomes between 'less tight' (target diastolic blood pressure [dBP] of 100 mmHg) versus 'tight' control (target dBP of 85 mmHg) in the CHIPS Trial (ISRCTN 71416914, http://pre-empt.cfri.ca/;CHIPS) depended on the choice of labetalol or methyldopa, the two most commonly used antihypertensive agents in CHIPS. DESIGN: Secondary analysis of CHIPS Trial data. SETTING: International multicentre randomised controlled trial (94 sites, 15 countries). POPULATION OR SAMPLE: A total of 987 women with non-severe non-proteinuric pregnancy hypertension. METHODS: Logistic regression was used for comparisons of 'less tight' versus 'tight' control among women treated with labetalol (but not methydopa) versus methyldopa (but not labetalol). Analyses were adjusted for the influence of baseline factors, including use of any antihypertensive therapy at randomisation. MAIN OUTCOME MEASURES: Main CHIPS Trial outcomes: primary (perinatal loss or high-level neonatal care for > 48 hours), secondary (serious maternal complications), birthweight < 10th centile, severe maternal hypertension, pre-eclampsia, and delivery at < 34 or < 37 weeks. RESULTS: Of 987 women in CHIPS, antihypertensive therapy was taken by 566 women at randomisation (labetalol 111 ['less tight'] versus 127 ['tight'] or methyldopa 126 ['less tight'] versus 117 ['tight']) and 815 women after randomisation (labetalol 186 ['less tight'] versus 247 ['tight'] and methyldopa by 98 ['less tight'] versus 126 ['tight']). Following adjustment, odds ratios for outcomes in 'less tight' versus 'tight' control were similar between antihypertensive groups according to 'at randomisation' and 'after randomisation' therapy. CONCLUSION: Outcomes for 'less tight' versus 'tight' control were not dependent on use of methyldopa or labetalol. TWEETABLE ABSTRACT: In the CHIPS Trial, maternal and infant outcomes were not dependent on use of labetalol or methyldopa.
File Format	HTM / HTML
ISSN	14700328
e-ISSN	14710528
Journal	BJOG: An International Journal of Obstetrics & Gynaecology
Issue Number	7
Volume Number	123
Language	English
Publisher	Wiley
Publisher Date	2016-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Obstetrics Gynaecology
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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