| Author |
Seiler, S. Pirpamer, L. Gesierich, B. Hofer, E. Duering, M. Pinter, D. Jouvent, E. Fazekas, F. Mangin, J-F Chabriat, H. Ropele, S. Schmidt, R. |
| Description |
Author Affiliation: Seiler S ( From the Department of Neurology (S.S., L.P., E.H., D.P., F.F., S.R., R.S.).); Pirpamer L ( From the Department of Neurology (S.S., L.P., E.H., D.P., F.F., S.R., R.S.).); Gesierich B ( Institute for Stroke and Dementia Research (B.G., M.D.), Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.); Hofer E ( From the Department of Neurology (S.S., L.P., E.H., D.P., F.F., S.R., R.S.).); Duering M ( Institute of Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria.); Pinter D ( Institute for Stroke and Dementia Research (B.G., M.D.), Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.); Jouvent E ( From the Department of Neurology (S.S., L.P., E.H., D.P., F.F., S.R., R.S.).); Fazekas F ( Department of Neurology (E.J., H.C.), Institut National de la Santé et de la Recherche Médicale, UMR-740, Centre Hospitalo-Universitaire Lariboisière, Paris, France.); Mangin JF ( From the Department of Neurology (S.S., L.P., E.H., D.P., F.F., S.R., R.S.).); Chabriat H ( Neurospin (J.-F.M.), Commissariat à l'Energie Atomique et aux Energies Alternatives Saclay, Gif/Yvette, France.); Ropele S ( Department of Neurology (E.J., H.C.), Institut National de la Santé et de la Recherche Médicale, UMR-740, Centre Hospitalo-Universitaire Lariboisière, Paris, France.); Schmidt R ( From the Department of Neurology (S.S., L.P., E.H., D.P., F.F., S.R., R.S.).) |
| Abstract |
BACKGROUND AND PURPOSE: Gait disturbances in the elderly are disabling and a major public health issue but are poorly understood. In this multimodal MR imaging study, we used 2 voxel-based analysis methods to assess the voxelwise relationship of magnetization transfer ratio and white matter hyperintensity location with gait velocity in older adults. MATERIALS AND METHODS: We assessed 230 community-dwelling participants of the Austrian Stroke Prevention Family Study. Every participant underwent 3T MR imaging, including magnetization transfer imaging. Voxel-based magnetization transfer ratio-symptom mapping correlated the white matter magnetization transfer ratio of each voxel with gait velocity. To assess a possible relationship between white matter hyperintensity location and gait velocity, we applied voxel-based lesion-symptom mapping. RESULTS: We found a significant association between the magnetization transfer ratio within the forceps minor and gait velocity (ß = 0.134; 95% CI, 0.011-0.258; = .033), independent of demographics, general physical performance, vascular risk factors, and brain volume. White matter hyperintensities did not significantly change this association. CONCLUSIONS: Our study provides new evidence for the importance of magnetization transfer ratio changes in gait disturbances at an older age, particularly in the forceps minor. The histopathologic basis of these findings is yet to be determined. |
