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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Livnat, Galit Lerner, Aaron Hakim, Fahed Eshach-Adiv, Orly Berkowitz, Drora Bentur, Lea |
| Description | Country affiliation: Israel Author Affiliation: Livnat G ( Pediatric Pulmonary Unit, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel.) |
| Abstract | AIM: Our aim was to determine bronchial hyper-responsiveness (BHR) and fractional exhaled NO (FeNO) in a cohort followed and treated for Crohn's disease (CD) in a Pediatric Gastroenterology Unit. METHODS: Consecutive children with CD were referred to the Pediatric Pulmonary Unit. Each patient completed a questionnaire, followed by spirometry, methacholine challenge test (MCT) and determination of FeNO. The control group included patients evaluated for functional cough who had negative MCT. RESULTS: Twenty-three children and young adults (mean age, 17.39 ± 2.96 years) with CD were compared to 24 healthy controls. 20/23 patients received immunomodulating treatment. Forced expiratory volume in 1 sec (FEV1) was significantly lower prior to (93.74 ± 10.81%, p = 0.009) and at the end of (78.91 ± 18.39%, p = 0.001) the MCT in the CD group compared with the control group (102.2 ± 10.477% and 95.33 ± 11.075%, respectively). Bronchial hyper-responsiveness was observed in 30.4% of patients with CD. FeNO levels were 15.37 ± 24.17 in CD and 11.38 ± 5.42 in the control group (p = 0.21). Neither the response to MCT nor FeNO levels were affected by the disease duration or activity index. CONCLUSION: In our series, BHR is less frequent than previously described in children with CD. We hypothesize that our finding could result from immunomodulating treatments or lower disease activity. |
| File Format | HTM / HTML |
| ISSN | 08035253 |
| Issue Number | 9 |
| Volume Number | 101 |
| e-ISSN | 16512227 |
| Journal | Acta Paediatrica |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-09-01 |
| Publisher Place | Norway |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pediatrics Bronchial Hyperreactivity Metabolism Crohn Disease Physiopathology Nitric Oxide Adolescent Breath Tests Bronchial Provocation Tests Drug Therapy Female Humans Immunomodulation Male Spirometry Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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