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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jägerstad, Margaretha |
| Spatial Coverage | United States Europe Canada |
| Description | Country affiliation: Sweden Author Affiliation: Jägerstad M ( Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden. Margaretha.Jagerstad@slu.se) |
| Abstract | UNLABELLED: The prevalence of neural tube defect (NTD)-affected pregnancies ranges between 0.4 and 2/1000 pregnancies in EU. NTDs result in severe malformations and sometimes miscarriages. Children born with NTD suffer for the rest of their life of disability and chronic healthcare issues, and many women therefore choose termination of pregnancy if NTD is diagnosed prenatally. Women planning for pregnancy are recommended to eat 400 µg folic acid/d, whereas average figures across Europe indicate intakes of â¼250 µg/d for women of fertile age, a gap that could be bridged by implementation of folic acid fortification. The results of mandatory folic acid fortifications introduced in USA and Canada are a decrease between 25 and 45% of NTD pregnancies. CONCLUSION: Evidence-based NTD prophylaxis is now practised in more than 60 countries worldwide. EU countries worry over possible cancer risks, but ignore a wealth of studies reporting decreasing cancer risks with folate intakes at recommended levels. Currently, there are indications of a U-shaped relationship, that is, higher cancer risks at low folate intakes (<150 µg/day) and highly elevated folate intakes (>1 mg/day), respectively. However neither the global World Cancer Research review nor EU's European Food Safety Authority report present data on increased cancer risk at physiological folate intake levels. Therefore, EU should act to implement folic acid fortification as NTD prophylaxis as soon as possible. |
| File Format | HTM / HTML |
| ISSN | 08035253 |
| Issue Number | 10 |
| Volume Number | 101 |
| e-ISSN | 16512227 |
| Journal | Acta Paediatrica |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-10-01 |
| Publisher Place | Norway |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pediatrics Dietary Supplements Standards Folic Acid Administration & Dosage Food, Fortified Neoplasms Chemically Induced Neural Tube Defects Prevention & Control Pregnancy Complications Canada Epidemiology Adverse Effects Statistics & Numerical Data Dose-response Relationship, Drug Europe Female Flour Global Health Guidelines As Topic Humans Mandatory Programs Nutritional Requirements Pregnancy Prevalence Program Evaluation Risk Assessment United States Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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