NDLI: Low vitamin D levels are associated with impaired virologic response to PEGIFNâ+âRBV therapy in HIV-hepatitis C virus coinfected patients.

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Low vitamin D levels are associated with impaired virologic response to PEGIFNâ+âRBV therapy in HIV-hepatitis C virus coinfected patients.

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Low vitamin D levels are associated with impaired virologic response to PEGIFNâ+âRBV therapy in HIV-hepatitis C virus coinfected patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mandorfer, Mattias Reiberger, Thomas Payer, Berit A. Ferlitsch, Arnulf Breitenecker, Florian Aichelburg, Maximilian C. Obermayer-Pietsch, Barbara Rieger, Armin Trauner, Michael Peck-Radosavljevic, Markus
Description	Country affiliation: Austria Author Affiliation: Mandorfer M ( Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna A-1090, Austria.)
Abstract	BACKGROUND: Low 25-hydroxyvitamin D [25(OH)D] levels are commonly found in HIV-hepatitis C virus (HCV) coinfected patients and are associated with liver fibrosis. No association between 25(OH)D levels and response to pegylated interferon -2a/2b plus ribavirin (PEGIFNâ+âRBV) has yet been reported for HIV-HCV coinfected patients. DESIGN: Epidemiological characteristics, HIV and HCV infection parameters, liver biopsies, as well as data on virologic response was available in 65 patients who received chronic hepatitis C (CHC) therapy with PEGIFNâ+âRBV within a prospective trial. 25(OH)D levels were retrospectively assessed using stored screening serum samples obtained within 35 days prior to CHC treatment. METHODS: According to their 25(OH)D levels, patients were assigned to the normal (>30âng/ml; D-NORM), the insufficiency (10-30âng/ml; D-INSUFF), or the deficiency (<10âng/ml; D-DEF) group. HCV-GT 1/4, high HCV-RNA load (>6â×â10âIU/ml), advanced liver fibrosis (METAVIR F3/F4), and IL28B rs12979860non-C/C were considered as established risk factors for treatment failure in HIV-HCV coinfected patients. RESULTS: Thirty-seven (57%) and 15 (23%) patients presented with D-INSUFF and D-DEF, respectively, whereas only 13 (20%) patients had normal 25(OH)D levels. Substantial differences in cEVR (D-NORM 92% vs. D-INSUFF 68% vs. D-DEF 47%; Pâ=â0.008) and SVR (D-NORM 85% vs. D-INSUFF 60% vs. D-DEF 40%; Pâ=â0.029) rates were observed between 25(OH)D subgroups. Especially in difficult-to-treat patients with multiple (three to four) established risk factors, low 25(OH)D levels were clearly associated with lower rates of SVR [patients without 25(OH)D deficiency 52% vs. D-DEF 0%; Pâ=â0.012]. CONCLUSION: Low 25(OH)D levels may impair virologic response to PEGIFNâ+âRBV therapy, especially in difficult-to-treat patients. Vitamin D supplementation should be considered and evaluated prospectively in HIV-HCV coinfected patients receiving CHC treatment.
File Format	HTM / HTML
ISSN	02699370
Issue Number	2
Volume Number	27
e-ISSN	14735571
Journal	AIDS
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2013-01-14
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Antiviral Agents Therapeutic Use Hiv Infections Blood Hepatitis C, Chronic Vitamin D Deficiency Vitamin D Adult Coinfection Drug Therapy, Combination Female Hiv Complications Drug Therapy Hepacivirus Humans Interferon-alpha Male Polyethylene Glycols Prospective Studies Randomized Controlled Trials As Topic Recombinant Proteins Ribavirin Risk Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy Immunology

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