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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aziz, Mohamed Mostafa Takagi, Yasushi Hashimoto, Nobuo Miyamoto, Susumu |
| Description | Country affiliation: Japan Author Affiliation: Aziz MM ( Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.) |
| Abstract | OBJECTIVE: Cerebral arteriovenous malformations (AVMs) do not seem to be static congenital vascular malformations but rather are dynamically changing pathologies. In this work, we investigated the expression and possible activation of different signal transducers and activators of transcription (STAT) family members in AVM nidus. METHODS: Immunohistochemical analysis was conducted on 25 AVM specimens from 24 patients using antibodies against STATs 1, 3, 5, and 6 as well as their phosphorylated forms. Analysis was also undertaken to determine if there is any correlation between STAT activation and different clinical parameters of AVM patients. RESULTS: Our studies revealed that both STATs 1 and 3 were highly expressed in cerebral AVM, mainly in the endothelium of AVM blood vessels and perivascular infiltrating inflammatory cells within the nidus. STAT3 showed the most intense level of expression within the endothelium and perivascular infiltrating inflammatory cells. It was intensely expressed in the endothelium of 25 (100%) specimens and in the infiltrating inflammatory cells of 24 (96%) specimens. The expression of the phospho-STATs 1 and 3 was also high in the endothelium and perivascular infiltrating inflammatory cells indicating activation of STATs 1 and 3 in AVM. We could not find any significant effect of hemorrhage or preoperative embolization, or other clinical parameters, on the activation of STATs 1 and 3 in cerebral AVMs. CONCLUSION: We obtained evidence for significant overexpression and activation of both STATs 1 and 3 in cerebral AVM, thus suggesting an important role for these proteins in mediating the pathophysiology of cerebral AVM. |
| File Format | HTM / HTML |
| ISSN | 18788750 |
| Issue Number | 5 |
| Volume Number | 78 |
| e-ISSN | 18788769 |
| Journal | World Neurosurgery |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurosurgery Intracranial Arteriovenous Malformations Metabolism Physiopathology Stat1 Transcription Factor Stat3 Transcription Factor Adolescent Adult Aged Child Child, Preschool Endothelium, Vascular Female Humans Immunohistochemistry Male Middle Aged Phosphorylation Physiology Stat5 Transcription Factor Stat6 Transcription Factor Signal Transduction Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery |
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