NDLI: CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-κB regulation in breast cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Tingting Miao, Zhifeng Wang, Zhenning Xu, Yingying Wu, Jianhua Liu, Xingyu You, Yi Li, Jiguang
Description	Country affiliation: China Author Affiliation: Zhao T ( Department of Surgical Oncology and General Surgery, First Affiliated Hospital, China Medical University, 155 North Nanjing Street, Heping District, Shenyang City, 110001, China.)
Abstract	CARMA3 was recently reported to be overexpressed in several cancers and associated with malignant behavior of cancer cells. However, the expression pattern and biological roles of CARMA3 in breast cancer have not been reported. In the present study, we found that CARMA3 was overexpressed in 41.9 % of breast cancer specimens. Significant association was observed between CARMA3 overexpression and TNM stage (p = 0.0223), tumor size (p = 0.0227), and ErbB-2 status (p = 0.0049). Furthermore, knockdown of CARMA3 expression in MDA-MB-435 cells with high endogenous expression decreased cell proliferation and sensitized cell to paclitaxel-induced apoptosis, while overexpression of CARMA3 in MDA-MB-231 cell line promoted cell proliferation and inhibited apoptosis. Further analysis showed that CARMA3 depletion downregulated, and its overexpression upregulated cyclin D1, Bcl-2, and p-IκB levels. In conclusion, our study demonstrated that CARMA3 is overexpressed in breast cancers. CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factor-kappaB signaling.
File Format	HTM / HTML
ISSN	10104283
Issue Number	5
Volume Number	34
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Antineoplastic Agents, Phytogenic Pharmacology Apoptosis Drug Effects Breast Neoplasms Metabolism Card Signaling Adaptor Proteins Nf-kappa B Paclitaxel Pathology Genetics Case-control Studies Cell Line, Tumor Cell Proliferation Cyclin D1 Female Gene Expression Humans Mammary Glands, Human Middle Aged Proto-oncogene Proteins C-bcl-2 Signal Transduction Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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