NDLI: Checkpoint inhibitors in immunotherapy of ovarian cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Dong-hui Guo, Liang Wu, Xiao-hua
Description	Author Affiliation: Wang DH ( First Department of Gynecology, Cangzhou Central Hospital, Cangzhou, 061001, Hebei, China, czwangdonghui@hotmail.com.)
Abstract	The treatment of ovarian cancer is a major challenge in oncology as mortality from ovarian cancer remains very high. The immune system plays a critical role in controlling cancer through a dynamic relationship with cancer cells. Immunotherapy can establish a sustained immune system response against recurring cancer cells leading to long-term remissions for ovarian cancer patient. The use of immune checkpoint inhibitors, which work by targeting molecules that serve as checks and balances in the regulation of immune responses, might be a promising avenue of immunotherapeutic research in ovarian cancer. In this review, we have focused on the potential of certain immune checkpoint inhibitors, such as anti-cytotoxic T lymphocyte antigens, anti-programmed death agents, and anti-program death ligands against ovarian cancer, with their mechanism of actions. Also, the problems arising due to checkpoint inhibitor immunotherapy have been discussed in this review. Checkpoint inhibitor immunotherapy is still in early-phase testing for ovarian cancer. Understanding the pivotal role of the tumor microenvironment in suppressing anticancer immunity, the unique adverse effects profiles of these agents, and the exploration of combinatorial treatment regimens will ultimately lead to enhance the efficacy of ovarian cancer immunotherapies and improved patient care.
File Format	HTM / HTML
ISSN	10104283
Issue Number	1
Volume Number	36
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2015-01-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Antineoplastic Agents Pharmacology Immunologic Factors Ovarian Neoplasms Immunology Animals Therapeutic Use Apoptosis Drug Effects Cell Cycle Checkpoints Female Humans Immunotherapy Therapy T-lymphocytes, Cytotoxic Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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