NDLI: Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 39

Year: 2016 Volume: 37

Year: 2016 Volume: 37 Issue: 8

Year: 2016 Volume: 37 Issue: 7

Year: 2016 Volume: 37 Issue: 6

Year: 2016 Volume: 37 Issue: 5

Downregulation of miR-148b as biomarker for early detection of hepatocellular carcinoma and may serve as a prognostic marker.

Downregulation of microRNA-217 and microRNA-646 acts as potential predictor biomarkers in progression, metastasis, and unfavorable prognosis of human osteosarcoma.

Downregulation of miR-185 and upregulation of miR-218 expression may be potential diagnostic and prognostic biomarkers of human chondrosarcoma.

Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling.

Ultrastructural changes of mitochondria in human retinoblastoma: correlation with tumor differentiation and invasiveness.

PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer.

Anti-cancer effect of metformin by suppressing signaling pathway of HER2 and HER3 in tamoxifen-resistant breast cancer cells.

MicroRNA-15a-5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF.

MicroRNA-143 replenishment re-sensitizes colorectal cancer cells harboring mutant, but not wild-type, KRAS to paclitaxel treatment.

Glabridin arrests cell cycle and inhibits proliferation of hepatocellular carcinoma by suppressing braf/MEK signaling pathway.

The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line.

Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype.

Sodium glycididazole enhances the radiosensitivity of laryngeal cancer cells through downregulation of ATM signaling pathway.

Clinicopathological characteristics and liver stem cell marker expression in hepatocellular carcinoma involving bile duct tumor thrombi.

Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway.

The involvement of hematopoietic pre-B cell leukemia transcription factor-interacting protein in regulating epithelial-mesenchymal transition of human spinal glioblastoma.

The relationship between five non-synonymous polymorphisms within three XRCC genes and gastric cancer risk in a Han Chinese population.

Downregulation of betaine homocysteine methyltransferase (BHMT) in hepatocellular carcinoma associates with poor prognosis.

EZH2 mediates ATO-induced apoptosis in acute myeloid leukemia cell lines through the Wnt signaling pathway.

Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.

The overexpression of miR-30a affects cell proliferation of chondrosarcoma via targeting Runx2.

MicroRNA-125b suppresses the epithelial-mesenchymal transition and cell invasion by targeting ITGA9 in melanoma.

Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis

Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.

Prognostic significance of ß2-adrenergic receptor expression in malignant melanoma.

NIK- and IKKß-binding protein promotes colon cancer metastasis by activating the classical NF-κB pathway and MMPs.

High expression of FOXR2 in breast cancer correlates with poor prognosis.

Chronic unpredictable stress deteriorates the chemopreventive efficacy of pomegranate through oxidative stress pathway.

Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53.

Increased expression of MyD88 and association with paclitaxel resistance in breast cancer.

Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia.

PGC-1ß regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways.

Wnt/ß-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma.

Regulatory effects of ΔFosB on proliferation and apoptosis of MCF-7 breast cancer cells.

MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation

CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment.

Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. (Part 2)

The involvement of anterior gradient 2 in the stromal cell-derived factor 1-induced epithelial-mesenchymal transition of glioblastoma.

Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma.

Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling.

Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance

Decreased expression of BRCA1-associated protein 1 predicts unfavorable survival in gastric adenocarcinoma

HER2/ERBB2 immunoreactivity in human retinoblastoma.

Nuclear PARP1 expression and its prognostic significance in breast cancer patients.

Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway.

Gene polymorphisms and oral cancer risk in tobacco habitués.

Epithelial-mesenchymal transition plays a critical role in drug resistance of hepatocellular carcinoma cells to oxaliplatin.

Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. (Part 1)

Association between interleukin 8 -251 A/T and +781 C/T polymorphisms and osteosarcoma risk in Chinese population: a case-control study.

Association of FokI polymorphism of vitamin D receptor with urothelial bladder cancer in Tunisians: role of tobacco smoking and plasma vitamin D concentration.

The alkyllysophospholipid edelfosine enhances TRAIL-mediated apoptosis in gastric cancer cells through death receptor 5 and the mitochondrial pathway.

Functional characterization of the tumor suppressor CMTM8 and its association with prognosis in bladder cancer.

13-Oxyingenol dodecanoate, a cytotoxic ingenol derivative, induces mitochondrial apoptosis and caspase-dependent Akt decrease in K562 cells.

Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma.

MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.

Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas.

Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.

The small conductance calcium-activated potassium channel 3 (SK3) is a molecular target for Edelfosine to reduce the invasive potential of urothelial carcinoma cells

The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect?

Does the addition of drugs targeting the vascular endothelial growth factor pathway to first-line chemotherapy increase complete response? A meta-analysis of randomized clinical trials.

Quercetin induces apoptosis and enhances 5-FU therapeutic efficacy in hepatocellular carcinoma.

Enhanced Wnt signaling by methylation-mediated loss of SFRP2 promotes osteosarcoma cell invasion.

Overexpression of iASPP-SV in glioma is associated with poor prognosis by promoting cell viability and antagonizing apoptosis.

Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.

Inflammation and chemerin in colorectal cancer.

Genetic variants in IL12 influence both hepatitis B virus clearance and HBV-related hepatocellular carcinoma development in a Chinese male population.

Diagnostic marker signature for esophageal cancer from transcriptome analysis.

Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression.

Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.

Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent.

Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.

MicroRNA-17 family as novel biomarkers for cancer diagnosis: a meta-analysis based on 19 articles.

Prognostic significance of GPC5 expression in patients with prostate cancer.

H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma.

The expression levels of the sirtuins in patients with BCC.

Anticancer function of -solanine in lung adenocarcinoma cells by inducing microRNA-138 expression.

miR-874 suppresses the proliferation and metastasis of osteosarcoma by targeting E2F3.

MiR-195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1.

Postmastectomy radiotherapy benefit in Chinese breast cancer patients with T1-T2 tumor and 1-3 positive axillary lymph nodes by molecular subtypes: an analysis of 1369 cases.

MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS.

Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway.

Regulation of osteosarcoma cell invasion through osteopontin modification by miR-4262.

FAM172A is a tumor suppressor in colorectal carcinoma.

In vitro and in vivo anti-melanoma effects of Daphne gnidium aqueous extract via activation of the immune system.

Roles of phosphatidylinositol 3-kinase regulatory subunit alpha, activator protein-1, and programmed cell death 4 in diagnosis of papillary thyroid carcinoma.

Desacetyl nimbinene inhibits breast cancer growth and metastasis through reactive oxygen species mediated mechanisms.

Combination of miR-125b and miR-27a enhances sensitivity and specificity of AFP-based diagnosis of hepatocellular carcinoma.

Expression and clinical implication of S100A12 in gastric carcinoma.

Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.

Flavones induce immunomodulatory and anti-inflammatory effects by activating cellular anti-oxidant activity: a structure-activity relationship study.

Regulatory B cells contribute to the impaired antitumor immunity in ovarian cancer patients.

Promoter-associated endogenous and exogenous small RNAs suppress human bladder cancer cell metastasis by activating p21 (CIP1/WAF1) expression.

PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population.

Elevated serum soluble CD14 levels in chronic HBV infection are significantly associated with HBV-related hepatocellular carcinoma.

Down-regulation of SNX1 predicts poor prognosis and contributes to drug resistance in colorectal cancer.

Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase.

MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations.

Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk.

Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people.

Nutrient deprivation-related OXPHOS/glycolysis interconversion via HIF-1 /C-MYC pathway in U251 cells.

Zoledronic acid induces apoptosis via stimulating the expressions of ERN1, TLR2, and IRF5 genes in glioma cells.

Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT).

Comparative analysis of basaloid and conventional squamous cell carcinomas of the esophagus: prognostic relevance of clinicopathological features and protein expression.

Anticancer effects of tributyltin chloride and triphenyltin chloride in human breast cancer cell lines MCF-7 and MDA-MB-231.

In search of underlying mechanisms and potential drugs of melphalan-induced vascular toxicity through retinal endothelial cells using bioinformatics approach.

High expression of Naa10p associates with lymph node metastasis and predicts favorable prognosis of oral squamous cell carcinoma.

Acylglycerol kinase is over-expressed in early-stage cervical squamous cell cancer and predicts poor prognosis.

Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction.

Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy.

miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1.

Clinical significance and expression of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer.

Lysophosphatidic acid activates the RhoA and NF-κB through Akt/IκB signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation.

Silencing of WWP2 inhibits adhesion, invasion, and migration in liver cancer cells.

Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC.

miR-615-5p prevents proliferation and migration through negatively regulating serine hydromethyltransferase 2 (SHMT2) in hepatocellular carcinoma.

G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab.

SphK1 promotes tumor cell migration and invasion in colorectal cancer.

miR-27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK-SMAC/DIABLO-XIAP axis.

Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects.

MicroRNA-144 mediates metabolic shift in ovarian cancer cells by directly targeting Glut1.

17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy.

Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population.

The over-expression of FGFR4 could influence the features of gastric cancer cells and inhibit the efficacy of PD173074 and 5-fluorouracil towards gastric cancer.

Impact of IGF-1, IGF-1R, and IGFBP-3 promoter methylation on the risk and prognosis of esophageal carcinoma.

Influence of BCL2-938 C>A promoter polymorphism and BCL2 gene expression on the progression of breast cancer

The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization.

Synthesis and antitumor activity evaluation of a novel porphyrin derivative for photodynamic therapy in vitro and in vivo.

Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.

SLC27A4 regulate ATG4B activity and control reactions to chemotherapeutics-induced autophagy in human lung cancer cells.

Assessment of changes in expression and presentation of NKG2D under influence of MICA serum factor in different stages of breast cancer.

Identification of carboxyl terminal peptide of Fibrinogen as a potential serum biomarker for gastric cancer.

Effect of CD44 gene polymorphisms on risk of transitional cell carcinoma of the urinary bladder in Taiwan.

Distinct prognostic values of four-Notch-receptor mRNA expression in ovarian cancer.

Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway.

ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers.

Phenotype of circulating tumor cell: face-off between epithelial and mesenchymal masks.

Gankyrin regulates cell signaling network.

Letter regarding 'MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies' by Wu KP et al.

Missing link between microRNA and prostate cancer.

Profiling cell-free and circulating miRNA: a clinical diagnostic tool for different cancers.

Milky spots: omental functional units and hotbeds for peritoneal cancer metastasis.

Segmental distribution of some common molecular markers for colorectal cancer (CRC): influencing factors and potential implications.

Cancer stem cells, metabolism, and therapeutic significance.

HSPB1 polymorphisms might be associated with radiation-induced damage risk in lung cancer patients treated with radiotherapy

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers

Year: 2016 Volume: 37 Issue: 4

Year: 2016 Volume: 37 Issue: 3

Year: 2016 Volume: 37 Issue: 2

Year: 2016 Volume: 37 Issue: 1

Year: 2016 Volume: 37 Issue: Supplementary 1

Year: 2015 Volume: 36

Year: 2014 Volume: 35

Year: 2013 Volume: 34

Year: 2012 Volume: 33

Year: 2011 Volume: 32

Year: 2010 Volume: 31

Year: 2009 Volume: 30

Year: 2008 Volume: 29

Year: 2007 Volume: 28

Year: 2006 Volume: 27

Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yahya, Shaymaa M. M. Hamed, Ahmed R. Emara, Mohamed Soltan, Maha M. Abd-Ellatef, Gamal Eldein F. Abdelnasser, Salma M.
Description	Country affiliation: Egypt Author Affiliation: Yahya SM ( Hormones Department, Meical Division, National Research Centre, 33 El Bohouth st. (Former El Tahrir st.) Dokki, P.O. 12622, Giza, Egypt. yahshay10@yahoo.com.); Hamed AR ( Pharmaceutical Research Group, Center of Excellence for Advanced Sciences and Phytochemistry Department National Research Centre, 33 El Bohouth st. (Former El Tahrir st) Dokki, P.O. 12622, Giza, Egypt.); Emara M ( Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Ein Helwan, P.O.X: 11795, Cairo, Egypt.); Soltan MM ( Pharmaceutical Research Group, Center of Excellence for Advanced Sciences and Phytochemistry Department National Research Centre, 33 El Bohouth st. (Former El Tahrir st) Dokki, P.O. 12622, Giza, Egypt.); Abd-Ellatef GE ( Pharmaceutical and Drug Industries Research Division, Therapeutic Chemistry Department, National Research Center, 33 El Bohouth st. (Former El Tahrir st) Dokki, P.O. 12622, Giza, Egypt.); Abdelnasser SM ( Microbial Biotechnology Department, National Research Center, 33 El Bohouth st. (Former El Tahrir st) Dokki, P.O. 12622, Giza, Egypt.)
Abstract	Multidrug resistance (MDR) in various kinds of cancers represents a true obstacle which hinders the successes of most of current available chemotherapies. ATP-binding cassette (ABC) trasporter proteins have been shown to contribute to the majority of MDR in various types of malignancies. c-myc has recently been reported to participate, at least partly, in MDR to some types of cancers. This study aimed to test whether c-myc could play a role, solely or with coordination with other ABCs, in the resistance of HepG2 cells to doxorubicin (Dox). MDR has been induced in wild-type HepG2 and has been verified both on gene and protein levels. Various assays including efflux assays as well as siRNA targeting ABCB1 and c-myc have been employed to explore the role of both candidate molecules in MDR in HepG2. Results obtained, with regard to ABCB1 silencing on HepG2/Dox cells, have shown that ABCB1-deficient cells exhibited a significant reduction in ABCC1 expression as compared to ABCB1-sufficient cells. However, these cells did not show a significant reduction in other tested ABCs (ABCC5 and ABCC10) while c-myc silencing had no significant effect on any of the studied ABCs. Moreover, silencing of ABCB1 on HepG2 significantly increased fluorescent calcein retention in HepG2 cells as compared to the control cells while downregulation of c-myc did not have any effect on fluorescent calcein retention. Altogether, this work clearly demonstrates that c-myc has no role in MDR of HepG2 to Dox which has been shown to be ABCB1-mediated in a mechanism which might involve ABCC1.
File Format	HTM / HTML
ISSN	10104283
Issue Number	5
Journal	Tumor Biology
Volume Number	37
e-ISSN	14230380
Language	English
Publisher	Springer
Publisher Date	2016-05-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in