NDLI: Pilot study: association of traditional and genetic risk factors and new-onset diabetes mellitus following kidney transplantation.

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Pilot study: association of traditional and genetic risk factors and new-onset diabetes mellitus following kidney transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chakkera, H. A. Hanson, R. L. Raza, S. M. DiStefano, J. K. Millis, M. P. Heilman, R. L. Mulligan, D. C. Reddy, K. S. Mazur, M. J. Hamawi, K. Moss, A. A. Mekeel, K. L. Cerhan, J. R.
Description	Country affiliation: United States Author Affiliation: Chakkera HA ( Division of Transplantation Medicine, Mayo Clinic, 5777 E. Mayo Blvd., Phoenix, AZ 85259, Arizona, USA. chakkera.harini@mayo.edu)
Abstract	INTRODUCTION: New-onset diabetes mellitus, which occurs after kidney transplant and type 2 diabetes mellitus (T2DM), shares common risk factors and antecedents in impaired insulin secretion and action. Several genetic polymorphisms have been shown to be associated with T2DM. We hypothesized that transplant recipients who carry risk alleles for T2DM are 'tipped over' to develop diabetes mellitus in the posttransplant milieu. METHODS: We investigated the association of genetic and traditional risk factors present before transplantation and the development of new-onset diabetes mellitus after kidney transplantation (NODAT). Markers in 8 known T2DM-linked genes were genotyped using either the iPLEX assay or allelic discrimination (AD)-PCR in the study cohort testing for association with NODAT. We used univariate and multivariate logistic regression models for the association of pretransplant nongenetic and genetic variables with the development of NODAT. RESULTS: The study cohort included 91 kidney transplant recipients with at least 1 year posttransplant follow-up, including 22 who developed NODAT. We observed that increased age, family history of T2DM, pretransplant obesity, and triglyceridemia were associated with NODAT development. In addition, we observed positive trends, although statistically not significant, for association between T2DM-associated genes and NODAT. CONCLUSIONS: These findings demonstrated an increased NODAT risk among patient with a positive family history for T2DM, which, in conjunction with the observed positive predictive trends of known T2DM-associated genetic polymorphisms with NODAT, was suggestive of a genetic predisposition to NODAT.
File Format	HTM / HTML
ISSN	00411345
e-ISSN	18732623
DOI	10.1016/j.transproceed.2009.08.063
Journal	Transplantation Proceedings
Issue Number	10
Volume Number	41
Language	English
Publisher	Elsevier
Publisher Date	2009-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Transplantation__semicolon__medicine Diabetes Mellitus Epidemiology Genetics Kidney Transplantation Adverse Effects Polymorphism, Single Nucleotide Postoperative Complications Weight Gain Body Mass Index Cohort Studies Genotype Medical History Taking Pilot Projects Regression Analysis Risk Factors
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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