NDLI: Inhibition of inflammatory cytokine-induced response in human islet cells by withaferin A.

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Similar early complication rate in simultaneous pancreas and kidney recipients on tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus immunosuppressive regimens.

Anti-CD25 antibody (daclizumab) maintenance therapy in pancreas transplantation.

Alemtuzumab with rapid steroid taper in simultaneous kidney and pancreas transplantation: comparison to induction with antithymocyte globulin.

Simultaneous pancreas and kidney transplantation with concurrent allograft nephrectomy for recipients with prior renal transplants lost to BK virus nephropathy: two case reports.

Pancreas oxygen persufflation increases ATP levels as shown by nuclear magnetic resonance.

Persufflation improves pancreas preservation when compared with the two-layer method.

Continuous real-time viability assessment of kidneys based on oxygen consumption.

Improved method of human islet isolation for young donors.

Islet isolation from human pancreas with extended cold ischemia time.

Improved method of porcine pancreas procurement with arterial flush and ductal injection enhances islet isolation outcome.

Rapid quantitative assessment of the pig pancreas biopsy predicts islet yield.

The impact of ischemic stress on the quality of isolated pancreatic islets.

A new method to value efficiency of enzyme blends for pancreatic tissue digestion.

Assessment of human islet isolation with four different collagenases.

Tissue dissociation enzyme neutral protease assessment.

Culture of impure human islet fractions in the presence of alpha-1 antitrypsin prevents insulin cleavage and improves islet recovery.

Inhibition of inflammatory cytokine-induced response in human islet cells by withaferin A.

Excellence of suito index for assessing clinical outcome of islet transplantation.

Secretory unit of islet transplant objects (SUITO) index can predict outcome of intravenous glucose tolerance test.

Pancreata from pediatric donors restore insulin independence in adult insulin-dependent diabetes mellitus recipients.

Neurogenic differentiation 1 directs differentiation of cytokeratin 19-positive human pancreatic nonendocrine cells into insulin-producing cells.

An acidic pH and activation of phosphoinositide 3-kinase stimulate differentiation of pancreatic progenitors into insulin-producing cells.

Induction of insulin-producing cells from human pancreatic progenitor cells.

Comparison of fresh and cultured islets from human and porcine pancreata.

Effects of pancreas transplantation on oxidative stress in pulmonary tissue from alloxan-induced diabetic rats.

Pancreas transplantation prevents morphologic and ultrastructural changes in pulmonary parenchyma of alloxan-induced diabetic rats.

Vascularization of artificial beds for pancreatic islet transplantation in a rat model.

C5a-inhibitory peptide combined with gabexate mesilate prevents the instant blood-mediated inflammatory reaction in a rat model of islet transplantation.

Magnetic resonance imaging of transplanted mouse islets labeled with chitosan-coated superparamagnetic iron oxide nanoparticles.

Effect of triple costimulation blockade on islet allograft survival in sensitized mice.

Imaging of human islet vascularization using a dorsal window model.

A survey of the attitudes of scientists toward xenotransplantation in Taiwan.

Some ethical aspects of xenotransplantation in light of the proposed European directive on the protection of animals used for scientific purposes.

The attitude of Scottish citizens to xenotransplantation in the South East of Spain: an emerging population subgroup.

Are veterinary students in favor of xenotransplantation? An opinion study in a Spanish university with a xenotransplantation program.

Infection of porcine cells with human herpesviruses.

The in vitro protection of human decay accelerating factor and hDAF/heme oxygenase-1 transgenes in porcine aortic endothelial cells against sera of Formosan macaques.

In vitro production of multigene transgenic blastocysts via sperm-mediated gene transfer allows rapid screening of constructs to be used in xenotransplantation experiments.

ABO and RH1 blood group phenotyping in pigs (Sus scrofa) using microtyping cards.

Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model.

Left ventricular pressure measurement by telemetry is an effective means to evaluate transplanted heart function in experimental heterotopic cardiac xenotransplantation.

Super-high-dose islet transplantation is associated with high SUITO index and prolonged insulin independence: a case report.

ET-Kyoto ductal injection and density-adjusted purification combined with potent anti-inflammatory strategy facilitated single-donor islet transplantation: case reports.

Percutaneous embolization of periduodenal varix due to portal hypertension in a patient with kidney-pancreas transplantation: a case report.

First Congress of the Italian Society for Safety and Quality in Transplantation. Preface.

The Italian Society for Safety and Quality in Transplantation (SISQT).

Electrical safety during transplantation.

National policies for risk management in Italy.

Unintended transplantation of three organs from an HIV-positive donor: report of the analysis of an adverse event in a regional health care service in Italy.

Do 'silent' brain deaths affect potential organ donation?

Safety of bone marrow stem cell donation: a review.

Efficiency of the tissue procurement process: what evaluation tools?

Ensuring safety and quality of tissues in Italy: application of European directives.

The role of nurses in the risk management of organ and tissue donation.

Calcineurin inhibitors in renal transplantation still needed but in reduced doses: a review.

Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation.

C4d-positive renal allograft rejection biopsies in cyclosporine-treated patients: single-center incidence and outcome.

Kidney graft survival rates do not improve by era: the impact of the age factor.

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Frozen-section diagnosis in donor livers: error rate estimation of steatosis degree.

Liver transplant quality and safety plan in anesthesia and intensive care medicine.

Patient satisfaction among liver transplant recipients: single-center survey.

Transplantation of hematopoietic stem cells: role of national transplantation center.

Human de-epidermized dermis as a stem cell carrier.

A common polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene regulatory region influences MCP-1 expression and function of isolated human pancreatic islets.

Functional and survival analysis of isolated human islets.

Risk analysis of hematopoietic stem cell transplant process: failure mode, effect, and criticality analysis and hazard analysis critical control point methods integration based on guidelines to good manufacturing practice for medicinal product ANNEX 20 (February 2008).

Key role of staff competencies for patient and donor safety in a bone marrow transplantation unit: design and implementation of an accredited training and self-assessment program.

Patient satisfaction with nursing staff in bone marrow transplantation and hematology units.

Case report: HIV infection from a kidney transplant.

Case report: cystic fibrosis, lung transplantation, and the novel H1N1 flu.

Transplantation in Hungary--preface on the occasion of Transplantation Proceedings becoming the official journal of the Hungarian Transplantation Society.

Changes in pituitary adenylate cyclase-activating polypeptide following renal ischemia-reperfusion in rats.

Examination of protective effect of ischemic postconditioning after small bowel autotransplantation.

Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice.

Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia.

Arterial stiffness in chronic renal failure and after renal transplantation.

Insertion/Deletion polymorphism of Angiotensin-converting enzyme as a risk factor for chronic allograft nephropathy.

Heat shock protein polymorphism predisposes to urinary tract malformations and renal transplantation in children.

Results and complications after living related kidney transplantation in Hungary: 30 years' experience.

Small difference in international normalized ratio may yield a significant impact on prioritizing patients listed for liver transplantation.

Can a cutoff value for cystatin C in the operative setting be determined to predict kidney function after liver transplantation?

Outcome of liver transplantation based on donor graft quality and recipient status.

Incidence of nonmelanoma skin cancer after human organ transplantation: single-center experience in Hungary.

Changes in oxidative stress in patients screened for skin cancer after solid-organ transplantation.

Effect of tacrolimus on the excitatory synaptic transmission between the parallel fibers and pyramidal cells in the rat dorsal cochlear nucleus.

Significance and imaging of lumbar veins and early-branching arteries in planning living-donor laparoscopic nephrectomy: two case reports from 21 months' experience.

Spontaneous pneumomediastinum after kidney transplantation: case report.

Mitigation of cytokine storm by intraoperative use of renal replacement therapy during combined liver-kidney transplantation.

Smoking following renal transplantation in Hungary and its possible deleterious effect on renal graft function.

Should a complex uropathy be a contraindication for renal transplantation in children?

Renal grafts with multiple arteries: a relative contraindication for a renal transplant?

Role of major histocompatibility complex and ethnicity in acute renal graft rejection.

Risk factors for Banff borderline acute rejection in protocol biopsies and effect on renal graft function.

Long-term complications and survival of patients after orthotopic liver transplantation.

Anesthetic risk factors associated with early mortality in pediatric liver transplantation.

Surgical technique in cadaveric donors for partial hand allotransplant in patients with rheumatoid arthritis.

Successful renal transplantation from a deceased donor with pesticide intoxication: a case report.

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Inhibition of inflammatory cytokine-induced response in human islet cells by withaferin A.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peng, H. Olsen, G. Tamura, Y. Noguchi, H. Matsumoto, S. Levy, M. F. Naziruddin, B.
Description	Country affiliation: United States Author Affiliation: Peng H ( Institute of Biomedical Studies, Baylor University, Waco, Texas, USA.)
Abstract	BACKGROUND: After islet cell transplantation, a substantial mass of islets are lost owing to nonspecific inflammatory reactions. Cytokine exposure before or after transplantation can upregulate expression of proinflammatory genes via the nuclear factor-kappaB signaling pathway, eventually resulting in islet loss. OBJECTIVE: To test the effects of a naturally occurring nuclear factor-kappaB inhibitor, withaferin A, on regulation of inflammatory genes in human islets. METHODS: Human pancreatic islets were isolated using a modified Ricordi protocol. Purified islets were cultured for 2 days. The effect of withaferin A treatment on islet cell viability was examined using the fluorescein diacetate-propidium iodide dye exclusion test, and on function using a static glucose stimulation assay. Islet cells were treated with a cytokine mixture (50 U/mL of interleukin-1beta, 1000 U/mL of tumor necrosis factor-alpha, and 1000 U/mL of interferon-gamma) for 48 hours with or without withaferin A, 1 microg/mL. Treated islets were used for real-time polymerase chain reaction (PCR) array analysis for expression of inflammatory genes, and expression of other selected genes was analyzed using real-time PCR with single primers. RESULTS: Glucose stimulation and viability assays demonstrated that withaferin A was not toxic to islet cells. Of 84 inflammation-related genes examined using real-time PCR array analysis, 9 were significantly upregulated by cytokine treatment compared with the control group. However, addition of withaferin A to the culture significantly inhibited expression of all genes. CONCLUSION: Withaferin A significantly inhibits the inflammatory response of islet cells with cytokine exposure.
File Format	HTM / HTML
ISSN	00411345
Issue Number	6
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Inflammation Prevention & Control Islets Of Langerhans Transplantation Pathology Islets Of Langerhans Cytology Withanolides Pharmacology Cadaver Cell Culture Techniques Cell Separation Methods Cell Survival Drug Effects Physiology Cytokines Gene Expression Regulation Glucose Humans Genetics Reverse Transcriptase Polymerase Chain Reaction Tissue Donors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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