NDLI: Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.

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A high model for end-stage liver disease score should not be considered a contraindication to living donor liver transplantation.

Analysis of donor risk factors associated with graft outcomes in orthotopic liver transplantation.

Magnetic resonance cholangiography in living donor liver transplantation: comparison of preenhanced and post-gadolinium-enhanced methods.

Importance of awareness of perioperative social and physical situations of living donors for liver transplantation.

Postoperative liver dysfunction in living donors after left-sided graft hepatectomy: portal venous occlusion of the medial segment after lateral segmentectomy and hepatic venous congestion after left lobe hepatectomy.

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Donor quality of life after living donor liver transplantation: single-institute experience.

Change in donor quality of life after living donor liver transplantation surgery: a single-institution experience.

Single-port laparoscopy-assisted donor right hepatectomy in living donor liver transplantation: sensible approach or unnecessary hindrance?

Standardized less invasive living donor hemihepatectomy using the hybrid method through a short upper midline incision.

Living donor liver transplantation for the patients with portal vein thrombosis: use of an interpositional venous graft passed posteriorly to the pancreatic parenchyma without using jump graft.

Pain management of living liver donors with morphine with or without ketorolac.

Postoperative pain and influencing factors among living liver donors.

Effect of university of wisconsin and histidine-tryptophan-ketoglutarate preservation solutions on blood potassium levels of patients undergoing living-donor liver transplantation.

Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.

Experience using extended criteria donors in first 100 cases of deceased donor liver transplantation in Japan.

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High model for end-stage liver disease score as a predictor of survival during long-term follow-up after liver transplantation.

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Investigation of histological vascular invasion from preoperative evaluation in patients with hepatocellular carcinoma who underwent living donor liver transplantation.

Hepatocellular carcinoma downstaging in liver transplantation.

Clinical value of preoperative coronary risk assessment by computed tomographic arteriography prior to adult living donor liver transplantation.

Does lymphocyte cross-matching predict acute rejection and graft survival in liver transplantation?

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Cardiac output derived from arterial pressure waveform analysis in patients undergoing liver transplantation: validity of a third-generation device.

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Cardiac output derived from arterial pressure waveform analysis: validation of the third-generation software in patients undergoing orthotopic liver transplantation.

Tying a slipknot to an intubation stylet for facilitating insertion of a nasogastric tube in liver transplant recipients: a prospective, randomized study.

The effects of desflurane and isoflurane on hepatic and renal functions after right hepatectomy in living donors.

The relationship between postoperative intravenous patient-controlled fentanyl analgesic requirements and severity of liver disease.

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Long-term outcomes of portal Y-graft interposition for anomalous right portal veins in living donor liver transplantation.

Standardization of modified right lobe grafts to minimize vascular outflow complications for adult living donor liver transplantation.

Living donor right hepatectomy with inclusion of the middle hepatic vein: outcome in 200 donors.

Anatomic similarity of the hepatic artery and portal vein according to the donor-recipient relationship.

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Living donor liver transplantation in children with cholestatic liver disease: a single-center experience.

Hemodynamic changes during the anhepatic phase in pediatric patient with biliary atresia versus glycogen storage disease undergoing living donor liver transplantation.

Biliary complications and management in pediatric living donor liver transplantation for underlying biliary atresia.

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Primary versus salvage living donor liver transplantation for patients with hepatocellular carcinoma: impact of microvascular invasion on survival.

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Effectiveness of intraportal prostaglandin E1 administration after liver transplantation.

Recipient and perioperative risk factors associated with liver transplant graft outcomes.

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Impact of hepatic macrovesicular and microvesicular steatosis on the postoperative liver functions after right hepatectomy in living donors.

Younger age and presence of macrovascular invasion were independent significant factors associated with poor disease-free survival in hepatocellular carcinoma patients undergoing living donor liver transplantation.

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Pediatric liver transplantation for hepatoblastoma: a single center experience.

The risk factors to predict acute rejection in liver transplantation.

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Quality of life among liver transplantation patients.

Dilemmas across different overseas liver transplant stages: Taiwan transplant recipient families' perspectives.

Change in the type of work of postoperative liver transplant patients.

Intracellular interferon-Î³ staining analysis of donor-specific T-cell responses in liver transplant recipients.

Optimization of immunosuppressive therapy based on a multiparametric mixed lymphocyte reaction assay reduces infectious complications and mortality in living donor liver transplant recipients.

Regulatory T-cell activation among patients who displayed operational tolerance following intra-portal administration of donor-specific antigens in living donor liver transplantation.

Long-term recurrence-free survival after liver transplantation from an ABO-incompatible living donor for treatment of hepatocellular carcinoma exceeding Milano criteria in a patient with hepatitis B virus cirrhosis: a case report.

De novo ulcerative colitis and autoimmune hepatitis after living related liver transplantation from cytomegalovirus-positive donor to cytomegalovirus-negative recipient: a case report.

Complex vascular reconstruction using donor's vessel grafts in orthotopic liver transplantation.

Liver transplantation surgical techniques for extensive retroperitoneal tumor with major blood vessel involvement: a case report.

Using ileocolic artery for successful graft salvage in a recipient with hepatic artery thrombosis after living donor liver transplantation: case report.

Right posterior portal vein stenosis developed after living donor liver transplantation using a modified right lobe graft with a type 2 portal vein: a case report.

Isolated dissection of the superior mesenteric artery after living donor liver transplantation: a case report.

The inferior mesenteric vein to the left gonadal vein shunt for gastroesophageal varices and extrahepatic portal vein thrombosis after living donor liver transplantation: a case report.

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Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kashiwadate, T. Miyagi, S. Hara, Y. Akamatsu, Y. Kawagishi, N. Sekiguchi, S. Satomi, S.
Description	Country affiliation: Japan Author Affiliation: Kashiwadate T ( Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Sendai, Japan. kashiwadate-nhn@umin.ac.jp)
Abstract	BACKGROUND: Liver transplantation is an established treatment for end-stage liver disease. However, an ongoing problem worldwide concerning this treatment is the shortage of grafts. Although transplantation using grafts from non-heart-beating donors (NHBDs) is considered a promising solution, some researchers have reported that these liver grafts are associated with primary graft nonfunction and biliary complications. The purpose of this study was to establish a safe technique procuring liver grafts from marginal donors such as NHBDs. MATERIALS AND METHODS: Male Wistar rats were divided into three groups: (1) the heart-beating (HB) group, whose livers were retrieved from HB donors; (2) the non-HB (NHB) group, whose livers were retrieved from NHBDs that had experienced an apnea-induced agonal condition (for this group, livers were subjected to warm ischemia for 30 minutes after cardiac arrest); and (3) the recombinant human soluble thrombomodulin (ART-123) group, whose livers were retrieved in the same manner as the NHB group but pretreated with ART-123 (1 mg/kg) at the agonal stage. The livers were reperfused for 60 minutes with oxygenated Krebs-Henseleit bicarbonate buffer after cold preservation for 6 hours. RESULTS: Bile production and portal flow volume in the ART-123 group were significantly higher than those in the NHB group. Alanine aminotransferase levels in the ART-123 group were significantly lower than those in the NHB group. Histological findings showed the narrowing of sinusoidal spaces and necroses in the NHB group were more severe than those in the ART-123 group. CONCLUSIONS: These results suggest that thrombomodulin may improve the viability of liver grafts from NHBDs.
File Format	HTM / HTML
ISSN	00411345
Issue Number	2
Volume Number	44
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Liver Transplantation Adverse Effects Liver Drug Effects Surgery Reperfusion Injury Prevention & Control Reperfusion Warm Ischemia Alanine Transaminase Blood Animals Bile Metabolism Disease Models, Animal Humans Blood Supply Pathology Liver Circulation Male Necrosis Portal Vein Physiopathology Rats Rats, Wistar Recombinant Proteins Pharmacology Etiology Thrombomodulin Time Factors Tissue Survival Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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