NDLI: Post-transplant diabetes mellitus: is it associated with poor allograft outcomes in renal transplants?

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Obstacles of non-heart-beating donor kidney transplantation in Japan to date and future perspectives.

Japanese strategies to maximize heart and lung availabilities: experience from 100 consecutive brain-dead donors.

Factors predicting the usefulness of deceased donors.

The 'ABO cross-transplantation problem' in liver transplantation in Korea.

Does procurement technique affect posttransplant graft function in deceased donor liver transplantation?

Differential function of natural killer cells in the liver graft perfusate of Korean population.

Post-transplant diabetes mellitus: is it associated with poor allograft outcomes in renal transplants?

Comparison of QuantiFERON-TB Gold with tuberculin skin test for detection of latent tuberculosis infection before kidney transplantation.

Impact of flow cytometry crossmatch B-cell positivity on living renal transplantation.

Implication of donor-recipient age gradient in the prognosis of graft outcome after deceased-donor kidney transplantation.

Can the kidney weight and recipient body weight ratio predict long-term graft outcome in living donor kidney transplantation?

Is the graft function of living donor renal transplants associated with renal mass matching by computed tomography angiographic volumetry?

Contrast-enhanced magnetic resonance angiography in the early period after kidney transplantation.

Comparative analysis of ABO-incompatible living donor kidney transplantation with ABO-compatible grafts: a single-center experience in Korea.

The impact of time-zero biopsy on early graft outcomes after living donor kidney transplantation.

Clinical outcomes in kidney transplantation patients from deceased donors with acute kidney injury.

Comparison of peritoneal dialysis and hemodialysis after kidney transplant failure.

The clinical outcome of end-stage renal disease patients who return to peritoneal dialysis after renal allograft failure.

Comparison of the clinical characteristics of renal transplant recipients who underwent early versus late graft nephrectomy.

Decreased parathyroid Klotho expression is associated with persistent hyperparathyroidism after kidney transplantation.

Impact of vitamin D, bisphosphonate, and combination therapy on bone mineral density in kidney transplant patients.

Sirolimus: a switch option for mycophenolate mofetil-induced leukopenia in renal transplant recipients.

Characteristics of testosterone deficiency syndrome in men with chronic kidney disease and male renal transplant recipients: a cross-sectional study.

Clinical courses of renal transplant recipients with high BK viremia.

Monitoring and treatment for BK virus after kidney transplantation.

Presence of vesicoureteral reflux in the graft kidney does not adversely affect long-term graft outcome in kidney transplant recipients.

Liver transplantation in lymphoma patients with hepatitis B virus reactivation.

Prognostic value of model for end-stage liver disease scores in patients with fulminant hepatic failure.

Survival rates among patients awaiting deceased donor liver transplants at a single high-volume Korean center.

Role of hand-assisted laparoscopic surgery in living-donor right liver harvest.

Unification venoplasty to cope with recipient portal vein anomaly during living donor liver transplantation.

Importance of donor-recipient age gradient to the prediction of graft outcome after living donor liver transplantation.

Effect of donor-recipient age gradient on graft outcomes in deceased donor liver transplantation.

Comparison of the incidence of de novo malignancy in liver or kidney transplant recipients: analysis of 2673 consecutive cases in a single center.

Characteristics of recipients who achieved spontaneous operational tolerance in adult liver transplantation.

Graft function measured by transient elastography in living donor liver transplantation: preliminary.

Long-term survival outcomes for living donor liver transplant recipients with pathologically nonviable hepatocellular carcinoma.

A pilot study on the safety and efficacy of generic mycophenolate agent as conversion maintenance therapy in stable liver transplant recipients.

Long-term outcome of liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma.

Comparison between resection and transplantation in combined hepatocellular and cholangiocarcinoma.

Analysis of S gene mutation of the hepatitis B virus in adult liver transplant recipients showing resistance to hepatitis B immunoglobulin therapy.

Clinical outcomes and risk factors of hepatitis B virus recurrence in patients who received prophylaxis with entecavir and hepatitis B immunoglobulin following liver transplantation.

Clinical outcomes of Pneumocystis carinii pneumonia in adult liver transplant recipients.

Strategies to reduce infectious complication using epidemiologic data analysis in liver transplant recipients.

Pre-emptive therapy for the cytomegalovirus infection after liver transplantation in endemic areas and its optimal diagnostic method.

Post-transplant assessment of consciousness in acute-on-chronic liver failure patients undergoing liver transplantation using bispectral index monitoring.

Clinical outcome of idiopathic hepatic parenchymal infarct following living donor liver transplantation.

Risk-based long-term screening for hepatocellular carcinoma recurrence after living donor liver transplantation.

Outcomes of alpha 1,3-GT-knockout porcine heart transplants into a preclinical nonhuman primate model.

Fabrication of a biodegradable xenoantigen-free rat liver scaffold for potential drug screening applications.

Optimal device and method for transportation of isolated porcine islet.

Mouse adipose tissue-derived adult stem cells expressed osteogenic specific transcripts of osteocalcin and parathyroid hormone receptor during osteogenesis.

New culture medium concepts for cell transplantation.

Pseudoislet of hybrid cellular spheroids from commercial cell lines.

Novel supplier of mesenchymal stem cell: subacromial bursa.

Fragmin/protamine microparticle carriers as a drug repositioning strategy for cell transplantation.

L-carnitine protects against cyclosporine-induced pancreatic and renal injury in rats.

No-touch en bloc right lobe living-donor liver transplantation with inferior vena cava replacement for hepatocellular carcinoma close to retrohepatic inferior vena cava: case report.

Jejunal artery can be a useful option for arterial reconstruction in living donor liver transplantation when the suitable arterial inflow is absent.

A case of everolimus-associated chylothorax in a cardiac transplant recipient.

Successful extracorporeal membrane oxygenation for right heart failure after heart transplantation-2 case reports and literature review.

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Post-transplant diabetes mellitus: is it associated with poor allograft outcomes in renal transplants?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Choi, J. Y. Kwon, O. J.
Description	Author Affiliation: Choi JY ( Department of Surgery, College of Medicine, Hanyang University, Seoul, Korea.)
Abstract	BACKGROUND: Post-transplant diabetes mellitus (PTDM) is a common metabolic complication whose incidence ranges from 2 to 50%, reflecting wide variations in population type, criteria for diagnosis, and immunosuppressive regimen. PTDM is associated with poor graft outcomes and increased infections and cardiovascular disease following renal transplants. Therefore, we assessed the incidence of PTDM and examined the association between PTDM and graft function after transplantation. MATERIALS AND METHODS: We investigated 565 renal transplants in our center. The patients were divided into 2 groups, depending on the time of surgery: group 1 (n = 228, from January 1990 to December 1995) and group 2 (n = 377, from January 1996 to December 2011). In each group, patients were divided into no diabetes mellitus (non-DM), preexisting diabetes mellitus (pre-DM), and PTDM subgroups. PTDM was defined as fasting plasma glucose ≥126 mg/dL. We started treatment by modification of lifestyle and/or antidiabetic medication. All patients in group 1 received cyclosporine (CsA) and patients in group 2 received CsA or tacrolimus. We analyzed the clinical characteristics of recipients, serum creatinine levels, and long-term graft survival. RESULTS: The overall incidence of PTDM was 11.7% (n = 66); 9.2% (n = 21) in group 1, and 13.4% in group 2. There was a higher incidence of PTDM in the recipients who received tacrolimus than in those who received CsA (25.0% vs 9.5%, P < .001) and the delay before the appearance of PTDM was shorter (38.58 ± 6.94 vs 75.85 ± 7.67, P = .017). Also the tacrolimus dose (20.4l ± 4.28 ng/mL) at the time of PTDM diagnosis was above the therapeutic range (5-20 ng/mL). There were no significant differences in infection and cardiovascular complication rates between the non-DM, pre-DM, and PTDM patients in group 1. In group 2, the use of tacrolimus significantly increased the incidence of PTDM compared with CsA (P < .001). However, there were no significant differences between subgroups in other variables. Serum creatinine levels 10 years after renal transplantation (P = .756 in group 1 and P = .559 in group 2) and long-term graft survival in those groups were not significantly different (P = .067 in group 1 and P = .125 in group 2). CONCLUSION: Renal function and allograft outcomes are more impaired in patients with PTDM than in either non-DM or pre-DM patients. However, if regular screening of plasma glucose levels, early diagnosis, and appropriate treatment of PTDM are carried out, the risk of complications can be minimized and the long-term allograft outcomes improved.
File Format	HTM / HTML
ISSN	00411345
Issue Number	8
Volume Number	45
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Diabetes Mellitus Etiology Kidney Transplantation Adverse Effects Treatment Outcome Aged Cyclosporine Administration & Dosage Female Humans Immunosuppressive Agents Male Middle Aged Tacrolimus Transplantation, Homologous Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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