NDLI: Limited efficacy and unacceptable toxicity of cyclophosphamide for the induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sogawa, Hiroshi Boskovic, Svjetlan Nadazdin, Ognjenka Abrahamian, Greg Colvin, Robert B. Sachs, David H. Cosimi, A. Benedict Kawai, Tatsuo
Description	Country affiliation: United States Author Affiliation: Sogawa H ( Currently, Recanati/Miller Transplantation Institute, Mount Sinai Medical Center and Mount Sinai School of Medicine, New York, NY, USA.)
Abstract	To induce mixed chimerism and renal allograft tolerance in cynomolgus monkeys, cyclophosphamide (CP) and total body irradiation (TBI) were compared as part of a nonmyeloablative conditioning regimen. CP induced dose-dependent neutropenia and lymphopenia, but hematopoietic recovery was more rapid than that observed in the TBI group. Absolute B cell counts after CP were significantly higher (P<0.01) than those in the TBI group. With CP, a total dose of 200 mg/kg with CD154 blockade regularly induced multilineage chimerism. Nevertheless, the recipients failed to achieve long-term survival because of rejection (3 of 5), posttransplantation B cell lymphoma (1 of 5), and toxicities of CP (1 of 5). As previously reported, 3 Gy of TBI with either splenectomy or CD154 blockade induced mixed chimerism and renal allograft tolerance, with significantly less morbidity and mortality than that produced by CP. Thus, TBI is more effective and less toxic than CP as part of a nonmyeloablative regimen for the induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys.
File Format	HTM / HTML
ISSN	00411337
e-ISSN	15346080
DOI	10.1097/TP.0b013e3181821bac
Journal	Transplantation Journal
Issue Number	4
Volume Number	86
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2008-08-27
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Transplantation Cyclophosphamide Toxicity Kidney Transplantation Immunology Neutropenia Chemically Induced Transplantation Tolerance Drug Effects Animals Immunosuppressive Agents Leukocyte Count Macaca Fascicularis Neutrophils Transplantation Chimera Transplantation, Homologous
Content Type	Text
Resource Type	Article
Subject	Transplantation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Limited Efficacy and Unacceptable Toxicity of Cyclophosphamide for the Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys

COMPARISON OF LUNG AND KIDNEY ALLOGRAFTS IN INDUCTION OF TOLERANCE BY A MIXED-CHIMERISM APPROACH IN CYNOMOLGUS MONKEYS

Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys.

Stem Cell Mobilization and Collection for Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys1

Potential role of host effector memory CD8+ T cells in marrow rejection after mixed chimerism induction in cynomolgus monkeys.

Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys

PRECLINICAL AND CLINICAL STUDIES ON THE INDUCTION OF RENAL ALLOGRAFT TOLERANCE THROUGH TRANSIENT MIXED CHIMERISM

Tolerance in renal transplantation: is mixed chimerism the missing link?

Transplantation: induction of chimerism and immune tolerance using belatacept.

Limited efficacy and unacceptable toxicity of cyclophosphamide for the induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys.

Similar Documents

Limited Efficacy and Unacceptable Toxicity of Cyclophosphamide for the Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys

COMPARISON OF LUNG AND KIDNEY ALLOGRAFTS IN INDUCTION OF TOLERANCE BY A MIXED-CHIMERISM APPROACH IN CYNOMOLGUS MONKEYS

Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys.

Stem Cell Mobilization and Collection for Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys1

Potential role of host effector memory CD8+ T cells in marrow rejection after mixed chimerism induction in cynomolgus monkeys.

Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys

PRECLINICAL AND CLINICAL STUDIES ON THE INDUCTION OF RENAL ALLOGRAFT TOLERANCE THROUGH TRANSIENT MIXED CHIMERISM

Tolerance in renal transplantation: is mixed chimerism the missing link?

Transplantation: induction of chimerism and immune tolerance using belatacept.

Limited efficacy and unacceptable toxicity of cyclophosphamide for the induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys.