NDLI: Flerumettede fettsyrer og epilepsi.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Farmen, Anette Huuse Lossius, Morten I. Nakken, Karl O.
Description	Author Affiliation: Farmen AH ( Nevrologisk avdeling Sykehuset Innlandet Lillehammer Anders Sandviks gate 17 2609 Lillehammer. anette.huuse.farmen@sykehuset-innlandet.no)
Abstract	BACKGROUND: 30 % of patients with epilepsy have recurrent drug-resistent seizures. Some children with catastrophic epilepsy have responded well to a ketogenic diet. Polyunsaturated fatty acids are at least partly responsible for the anticonvulsive effect of this diet and could perhaps be used to treat epilepsy. MATERIAL AND METHODS: The paper is based on literature (published before June 2008) retrieved through a non-systematic search of the Cochrane and PubMed databases. The following search words were used: epilepsy, polyunsaturated fatty acids, clinical trials, ketogen diet, and treatment. Articles focusing on clinical aspects were selected. RESULTS AND INTERPRETATION: Articles on clinical studies and laboratory research were retrieved from Pubmed, while studies on ketogen diet were retrieved from Cochrane. Animal studies show that increased intake of polyunsaturated fatty acids can reduce the likelihood of epileptic seizures through various biochemical mechanisms. However, there is not sufficient evidence to conclude that polyunsaturated fatty acids have antiepileptic effects in people with epilepsy. More research is needed before polyunsaturated fatty acids can be presented as a treatment option for epilepsy.
File Format	HTM / HTML
ISSN	00292001
e-ISSN	08077096
Journal	Tidsskrift for Den norske legeforening
Issue Number	1
Volume Number	129
Language	Norwegian
Publisher	Norwegian Medical Association
Publisher Date	2009-01-01
Publisher Place	Norway
Access Restriction	Open
Subject Keyword	Discipline Medicine Anticonvulsants Administration & Dosage Epilepsy Diet Therapy Fatty Acids, Unsaturated Ketogenic Diet Animals Therapeutic Use Drug Therapy
Alternative Title	Polyunsaturated fatty acids and epilepsy
Content Type	Text
Resource Type	Article
Subject	Medicine

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Farmakoresistent epilepsi.

Fisk og omega-3-fettsyrer ved hjertesvikt.

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Flerumettede fettsyrer og epilepsi.

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