NDLI: Nedsatt følsomhet for thyreoideahormon.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kvistad, Silje Agnethe Stokke Methlie, Paal Løvås, Kristian Sagen, Jørn V.
Description	Author Affiliation: Kvistad SA ( Hormonlaboratoriet Haukeland universitetssykehus.); Methlie P ( Medisinsk avdeling Haukeland universitetssykehus.); Løvås K ( Medisinsk avdeling Haukeland universitetssykehus og Klinisk institutt 2 Universitetet i Bergen.); Sagen JV ( Hormonlaboratoriet Haukeland universitetssykehus og Klinisk institutt 2 Universitetet i Bergen og KG Jebsen Senter for diabetesforskning Universitetet i Bergen.)
Abstract	BACKGROUND: In conditions with impaired sensitivity to thyroid hormone, reduced effect of thyroid hormone is attributable to various defects. The purpose of this article is to give an overview of these conditions, as well as to provide updated knowledge on impaired sensitivity to thyroid hormone, also known as thyroid hormone resistance, with mutations in thyroid hormone receptor ß (TRß). MATERIAL AND METHOD: This article is based on a selection of English-language articles, and Norwegian original and review articles found in PubMed, and the authors' own experiences with this patient group. RESULTS: Thyroid hormone resistance has long been a recognised cause of the reduced effect of thyroid hormone. Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor (TR ), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3). The conditions vary in terms of their clinical picture and biochemical profile. INTERPRETATION: Based on clinical and biochemical findings, thyroid hormone resistance may be erroneously interpreted as hyperthyroidism. In patients with thyroid hormone resistance, the condition may be exacerbated if it is treated as hyperthyroidism. It is therefore essential to recognise the conditions and their differential diagnoses.
File Format	HTM / HTML
ISSN	00292001
e-ISSN	08077096
Journal	Tidsskrift for Den norske legeforening
Issue Number	7
Volume Number	136
Language	Norwegian
Publisher	Norwegian Medical Association
Publisher Date	2016-04-19
Publisher Place	Norway
Access Restriction	Open
Subject Keyword	Discipline Medicine Thyroid Hormone Resistance Syndrome Thyroid Hormones Monocarboxylic Acid Transporters Genetics Metabolism Mutation Thyroid Hormone Receptors Alpha Thyroid Hormone Receptors Beta Diagnosis
Alternative Title	Impaired sensitivity to thyroid hormone
Content Type	Text
Resource Type	Article
Subject	Medicine

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Two Novel Mutations in the Thyroid Hormone Receptor ß in Patients with Resistance to Thyroid Hormone (RTH ß): Clinical, Biochemical, and Molecular Data.

Nedsatt følsomhet for thyreoideahormon.

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Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha☆

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Nedsatt følsomhet for thyreoideahormon.