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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | McMullin, Nolan Lindsell, Christopher J. Lei, Lei Mafi, John Jois-Bilowich, Preeti Anantharaman, Venkataraman Pollack, Charles V. Hollander, Judd E. Gibler, W. Brian Hoekestra, James W. Diercks, Deborah Peacock, W. Frank |
| Description | Country affiliation: United States Author Affiliation: McMullin N ( The Cleveland Clinic, Cleveland, OH, USA.) |
| Abstract | INTRODUCTION: Troponin concentrations rising above an institutional cutpoint are used to define acute myocardial necrosis, yet it is uncertain what outcomes are associated with fluctuations in troponin that do not exceed this level. We evaluate the association between troponin fluctuations below an institutional upper limit of normal and acute coronary syndrome (ACS). MATERIALS AND METHODS: This was a post hoc analysis of the Internet tracking registry of ACS (i*trACS), which describes patients presenting to emergency departments (EDs) with suspected ACS across the spectrum of risk. Patients were included in this registry if they were at least 18 years old and had suspected ACS at the time of their ED visit. Inclusions in this analysis required that patients had at least 1 cardiac marker (creatine kinase-MB [CK-MB], troponin T, or troponin I) drawn twice within 6 hours of presentation, with both measures being below the institution's upper limit of normal. A marker change was defined as either an increase or decrease that exceeded 15% of the institutional upper limit of normal. Acute coronary syndrome was defined as a positive stress test, documented myocardial infarction, coronary revascularization, or death within 30 days of their ED admission. RESULTS: Of 17,713 patient visits, 2162 met inclusion and exclusion criteria. There were 1872 patient visits with 2 troponin results and 1312 with 2 CK-MB results. Patient visits with increasing troponin had increased odds of ACS compared with those with stable troponin levels (odds ratio, 3.6; 95% confidence interval, 1.4-9.2). Changing CK-MB and decreasing troponin were not associated with increased odds of ACS. CONCLUSIONS: Small increases in troponin concentration below the upper limit of normal are associated with increased odds of ACS. |
| File Format | HTM / HTML |
| ISSN | 07356757 |
| Issue Number | 2 |
| Volume Number | 29 |
| e-ISSN | 15328171 |
| Journal | The American Journal of Emergency Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Emergency Discipline Medicine Acute Coronary Syndrome Blood Creatine Kinase, Mb Form Myocardial Infarction Troponin I Troponin T Diagnosis Biological Markers Female Humans Male Middle Aged Outcome Assessment (health Care) Prognosis Registries Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine |
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